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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Karabacak, Mustafa Yigit, Mehmet Turkdogan, Kenan Ahmet Sert, Mehmet |
| Description | Author Affiliation: Karabacak M ( Department of Cardiology, Isparta State Hospital, Isparta, Turkey. Electronic address: drmustafa1979@hotmail.com.); Yigit M ( Department of Emergency Medicine, Bezimialem Foundation University, Istanbul, Turkey.); Turkdogan KA ( Department of Emergency Medicine, Bezimialem Foundation University, Istanbul, Turkey.); Sert M ( Department of Nephrology, Isparta State Hospital, Isparta, Turkey.) |
| Abstract | OBJECTIVE: Hypertensive crises, divided depending on the presence of target organ damage (TOD), are associated with increased cardiovascular mortality and morbidity. Monocyte chemoattractant protein-1 (MCP-1) is responsible for the recruitment of monocytes to sites of vascular inflammation. The aim of this study was to evaluate the role of vascular inflammation in development of TOD. METHOD: The patients were categorized according to the presence of TOD. Thirty-three patients (15 female; mean age, 68 ± 12 y) with TOD and 30 patients (14 female; mean age, 64 ± 12 y) without TOD were included to the study. In addition to routine laboratory parameters, neutrophil-lymphocyte ratio, uric acid, C-reactive protein (CRP), high sensitive CRP, and plasma MCP-1 levels were evaluated. RESULTS: Neutrophil counts, white blood cells, high sensitive CRP, and uric acid levels were higher in patients with hypertensive crises. More importantly, CRP (7.2 mg/dL [2-37.8 mg/dL] vs 4.6 mg/dL [1.5-14 mg/dL] vs 2.7 mg/dL [1-8.1 mg/dL], P < .01) and MCP-1 levels (546 pg/mL [236-1350 pg/mL] vs 407 pg/mL [78-942 pg/mL] vs 264 pg/mL [34-579 pg/mL], P < .01) were higher in the group with TOD compared with other groups. CONCLUSION: In conclusion, plasma MCP-1 levels were significantly higher in patients with TOD. According to our results, we suggest that increased vascular inflammation and MCP-1 levels might be associated with the development of TOD in hypertensive crisis. |
| File Format | HTM / HTML |
| ISSN | 07356757 |
| Issue Number | 4 |
| Volume Number | 33 |
| e-ISSN | 15328171 |
| Journal | The American Journal of Emergency Medicine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Emergency Discipline Medicine Biological Markers Blood Cardiovascular Diseases Etiology Hypertension Complications Aged C-reactive Protein Analysis Chemokine Ccl2 Emergency Service, Hospital Enzyme-linked Immunosorbent Assay Female Humans Inflammation Leukocyte Count Male Middle Aged Uric Acid Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine |
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