NDLI: Wheat Stripe Rust Resistance Protein WKS1 Reduces the Ability of the Thylakoid-Associated Ascorbate Peroxidase to Detoxify Reactive Oxygen Species.

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Wheat Stripe Rust Resistance Protein WKS1 Reduces the Ability of the Thylakoid-Associated Ascorbate Peroxidase to Detoxify Reactive Oxygen Species.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gou, Jin-Ying Li, Kun Wu, Kati Wang, Xiaodong Lin, Huiqiong Cantu, Dario Uauy, Cristobal Dobon-Alonso, Albor Midorikawa, Takamufi Inoue, Kentaro Sánchez, Juan Fu, Daolin Blechl, Ann Wallington, Emma Fahima, Tzion Meeta, Madhu Epstein, Lynn Dubcovsky, Jorge
Description	Country affiliation: China Author Affiliation: Gou JY ( Department of Plant Sciences, University of California, Davis, California 95616 State Key Laboratory of Genetic Engineering, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China.); Li K ( Department of Plant Sciences, University of California, Davis, California 95616 State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai'an, Shandong 271018, China.); Wu K ( Department of Plant Sciences, University of California, Davis, California 95616.); Wang X ( Department of Plant Sciences, University of California, Davis, California 95616.); Lin H ( Department of Plant Sciences, University of California, Davis, California 95616.); Cantu D ( Department of Viticulture and Enology, University of California, Davis, California 95616.); Uauy C ( John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom National Institute of Agricultural Botany, Cambridge CB3 0LE, United Kingdom.); Dobon-Alonso A ( John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom.); Midorikawa T ( Department of Plant Sciences, University of California, Davis, California 95616.); Inoue K ( Department of Plant Sciences, University of California, Davis, California 95616.); Sánchez J ( Department of Plant Sciences, University of California, Davis, California 95616.); Fu D ( State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai'an, Shandong 271018, China.); Blechl A ( U.S. Department of Agriculture-Agricultural Research Service, Western Regional Research Center, Albany, California 94710.); Wallington E ( National Institute of Agricultural Botany, Cambridge CB3 0LE, United Kingdom.); Fahima T ( Institute of Evolution and the Department of Evolutionary and Environmental Biology, University of Haifa, Haifa 31905, Israel.); Meeta M ( Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana 141004, Punjab, India.); Epstein L ( Department of Plant Pathology, University of California, Davis, California 95616.); Dubcovsky J ( Department of Plant Sciences, University of California, Davis, California 95616 Howard Hughes Medical Institute, Chevy Chase, Maryland 20815 jdubcovsky@ucdavis.edu.)
Abstract	Stripe rust is a devastating fungal disease of wheat caused by Puccinia striiformis f. sp tritici (Pst). The WHEAT KINASE START1 (WKS1) resistance gene has an unusual combination of serine/threonine kinase and START lipid binding domains and confers partial resistance to Pst. Here, we show that wheat (Triticum aestivum) plants transformed with the complete WKS1 (variant WKS1.1) are resistant to Pst, whereas those transformed with an alternative splice variant with a truncated START domain (WKS1.2) are susceptible. WKS1.1 and WKS1.2 preferentially bind to the same lipids (phosphatidic acid and phosphatidylinositol phosphates) but differ in their protein-protein interactions. WKS1.1 is targeted to the chloroplast where it phosphorylates the thylakoid-associated ascorbate peroxidase (tAPX) and reduces its ability to detoxify peroxides. Increased expression of WKS1.1 in transgenic wheat accelerates leaf senescence in the absence of Pst. Based on these results, we propose that the phosphorylation of tAPX by WKS1.1 reduces the ability of the cells to detoxify reactive oxygen species and contributes to cell death. This response takes several days longer than typical hypersensitive cell death responses, thus allowing the limited pathogen growth and restricted sporulation that is characteristic of the WKS1 partial resistance response to Pst.
File Format	HTM / HTML
ISSN	10404651
e-ISSN	1531298X
DOI	10.1105/tpc.114.134296
Journal	THE PLANT CELL ONLINE
Issue Number	6
Volume Number	27
Language	English
Publisher	American Society of Plant Biologists
Publisher Date	2015-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Botany Ascorbate Peroxidases Physiology Basidiomycota Plant Diseases Microbiology Plant Proteins Reactive Oxygen Species Metabolism Thylakoids Enzymology Triticum Pathogenicity Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Plant Science

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Wheat Stripe Rust Resistance Protein WKS1 Reduces the Ability of the Thylakoid-Associated Ascorbate Peroxidase to Detoxify Reactive Oxygen Species [OPEN]

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