NDLI: Interface-directed self-assembly of cell-laden microgels.

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Interface-directed self-assembly of cell-laden microgels.

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Year: 2010 Volume: 6 Issue: 7

Year: 2010 Volume: 6 Issue: 6

Year: 2010 Volume: 6 Issue: 5

Year: 2010 Volume: 6 Issue: 4

Year: 2010 Volume: 6 Issue: 3

Year: 2010 Volume: 6 Issue: 2

Year: 2010 Volume: 6 Issue: 1

Interface-directed self-assembly of cell-laden microgels.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zamanian, Behnam Masaeli, Mahdokht Nichol, Jason W. Khabiry, Masoud Hancock, Matthew J. Bae, Hojae Khademhosseini, Ali
Description	Country affiliation: United States Author Affiliation: Zamanian B ( Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School 65 Landsdowne Street, Cambridge, MA 02139, USA.)
Abstract	Cell-laden hydrogels show great promise for creating engineered tissues. However, a major shortcoming with these systems has been the inability to fabricate structures with controlled micrometer-scale features on a biologically relevant length scale. In this Full Paper, a rapid method is demonstrated for creating centimeter-scale, cell-laden hydrogels through the assembly of shape-controlled microgels or a liquid-air interface. Cell-laden microgels of specific shapes are randomly placed on the surface of a high-density, hydrophobic solution, induced to aggregate and then crosslinked into macroscale tissue-like structures. The resulting assemblies are cell-laden hydrogel sheets consisting of tightly packed, ordered microgel units. In addition, a hierarchical approach creates complex multigel building blocks, which are then assembled into tissues with precise spatial control over the cell distribution. The results demonstrate that forces at an air-liquid interface can be used to self-assemble spatially controllable, cocultured tissue-like structures.
File Format	HTM / HTML
ISSN	16136810
e-ISSN	16136829
DOI	10.1002/smll.200902326
Journal	Small
Issue Number	8
Volume Number	6
Language	English
Publisher	Wiley-VCH
Publisher Date	2010-04-23
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Discipline Nanotechnology Fibroblasts Cytology Hydrogels Chemical Synthesis Tissue Engineering Animals Cell Aggregation Cell Survival Mice Nih 3t3 Cells Tissue Scaffolds Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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