NDLI: Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery.

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Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bao, Hongqian Pan, Yongzheng Ping, Yuan Sahoo, Nanda Gopal Wu, Tongfei Li, Lin Li, Jun Gan, Leong Huat
Description	Country affiliation: Singapore Author Affiliation: Bao H ( School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.)
Abstract	The covalent functionalization of graphene oxide (GO) with chitosan (CS) is successfully accomplished via a facile amidation process. The CS-grafted GO (GO-CS) sheets consist of about 64 wt.% CS, which imparts them with a good aqueous solubility and biocompatibility. Additionally, the physicochemical properties of GO-CS are studied. As a novel nanocarrier, GO-CS is applied to load a water-insoluble anticancer drug, camptothecin (CPT), via π-π stacking and hydrophobic interactions. It is demonstrated that GO-CS possesses a superior loading capacity for CPT, and the GO-CS-CPT complexes show remarkably high cytotoxicity in HepG2 and HeLa cell lines compared to the pure drug. At the same time, GO-CS is also able to condense plasmid DNA into stable, nanosized complexes, and the resulting GO-CS/pDNA nanoparticles exhibit reasonable transfection efficiency in HeLa cells at certain nitrogen/phosphate ratios. Therefore, the GO-CS nanocarrier is able to load and deliver both anticancer drugs and genes.
File Format	HTM / HTML
ISSN	16136810
Issue Number	11
Volume Number	7
e-ISSN	16136829
Journal	Small
Language	English
Publisher	Wiley-VCH
Publisher Date	2011-06-06
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nanotechnology Chitosan Chemistry Drug Carriers Drug Delivery Systems Gene Transfer Techniques Graphite Nanoparticles Camptothecin Pharmacology Cell Death Drug Effects Cell Survival Chemical Synthesis Dna Metabolism Electrophoresis, Agar Gel Hela Cells Hep G2 Cells Humans Hydrogen-ion Concentration Magnetic Resonance Spectroscopy Microscopy, Atomic Force Ultrastructure Plasmids Potentiometry Spectrophotometry, Ultraviolet Static Electricity Thermogravimetry Transfection Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology

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