NDLI: Comparing intracellular stability and targeting of sulfobetaine quantum dots with other surface chemistries in live cells.

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Comparing intracellular stability and targeting of sulfobetaine quantum dots with other surface chemistries in live cells.

Year: 2012 Volume: 8 Issue: 6

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Comparing intracellular stability and targeting of sulfobetaine quantum dots with other surface chemistries in live cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Muro, Eleonora Fragola, Alexandra Pons, Thomas Lequeux, Nicolas Ioannou, Andriani Skourides, Paris Dubertret, Benoit
Description	Country affiliation: France Author Affiliation: Muro E ( Laboratoire Physique et Etude des Matériaux UMR8213, ESPCI ParisTech-CNRS - UPMC Sorbonne Universités, 10 rue Vauquelin, 75005 Paris, France.)
Abstract	The in vivo labeling of intracellular components with quantum dots (QDs) is very limited because of QD aggregation in the cell cytoplasm and/or QD confinement into lysosomal compartments. In order to improve intracellular targeting with QDs, various surface chemistries and delivery methods have been explored, but they have not yet been compared systematically with respect to the QD intracellular stability. In this work, the intracellular aggregation kinetics of QDs for three different surface chemistries based on ligand exchange or encapsulation with amphiphilic polymers are compared. For each surface chemistry, three delivery methods for bringing the nanoparticles into the cells are compared: electroporation, microinjection, and pinocytosis. It is concluded that the QD intracellular aggregation behavior is strongly dependent on the surface chemistry. QDs coated with dihydrolipoic acid-sulfobetaine (DHLA-SB) ligands diffuse freely in cells for longer periods of time than for QDs in the other chemistries tested, and they can access all cytoplasmic compartments. Even when conjugated to streptavidin, these DHLA-SB QDs remain freely diffusing inside the cytoplasm and unaggregated, and they are able to reach a biotinylated target inside HeLa cells. Such labeling was more efficient when compared to commercial streptavidin-conjugated QDs, which may be due to the smaller size of DHLA-SB QDs and/or to their superior intracellular stability.
File Format	HTM / HTML
ISSN	16136810
Issue Number	7
Volume Number	8
e-ISSN	16136829
Journal	Small
Language	English
Publisher	Wiley-VCH
Publisher Date	2012-04-10
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nanotechnology Betaine Analogs & Derivatives Quantum Dots Thioctic Acid Animals Chemistry Cytoplasm Metabolism Electroporation Embryo, Nonmammalian Hela Cells Humans Microinjections Xenopus Laevis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology

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