NDLI: Polymeric nanoparticles with sequential and multiple FRET cascade mechanisms for multicolor and multiplexed imaging.

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Polymeric nanoparticles with sequential and multiple FRET cascade mechanisms for multicolor and multiplexed imaging.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wagh, Anil Jyoti, Faidat Mallik, Sanku Qian, Steven Leclerc, Estelle Law, Benedict
Description	Country affiliation: United States Author Affiliation: Wagh A ( Department of Pharmaceutical Sciences, College of Pharmacy, Nursing and Allied Sciences, North Dakota State University, Department 2665, PO Box 6050, Fargo, ND 58108-6050, USA.)
Abstract	The ability to map multiple biomarkers at the same time has far-reaching biomedical and diagnostic applications. Here, a series of biocompatible poly(D,L-lactic-co-glycolic acid) and polyethylene glycol particles for multicolor and multiplexed imaging are reported. More than 30 particle formulations that exhibit distinct emission signatures (ranging from the visible to NIR wavelength region) are designed and synthesized. These particles are encapsulated with combinations of carbocyanine-based fluorophores DiO, Dil, DiD, and DiR, and are characterized as <100 nm in size and brighter than commercial quantum dots. A particle formulation is identified that simultaneously emits fluorescence at three different wavelengths upon a single excitation at 485 nm via sequential and multiple FRET cascade events for multicolor imaging. Three other particles that display maximum fluorescence intensities at 570, 672, or 777 nm for multiplexed imaging are also identified. These particles are individually conjugated with specific (Herceptin or IgG2A11 antibody) or nonspecific (heptaarginine) ligands for targeting and, thus, could be applied to differentiate different cancer cells from a cell mixture according to the expressions of cell-surface human epidermal growth factor receptor 2 and the receptor for advanced glycation endproducts. Using an animal model subcutaneously implanted with the particles, it is further demonstrated that the developed platform could be useful for in vivo multiplexed imaging.
File Format	HTM / HTML
ISSN	16136810
Issue Number	12
Volume Number	9
e-ISSN	16136829
Journal	Small
Language	English
Publisher	Wiley-VCH
Publisher Date	2013-06-24
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nanotechnology Diagnostic Imaging Methods Fluorescence Resonance Energy Transfer Nanoparticles Chemistry Polymers Lactic Acid Polyethylene Glycols Polyglycolic Acid Journal Article
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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