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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Geers, Bart De Wever, Olivier Demeester, Joseph Bracke, Marc De Smedt, Stefaan C. Lentacker, Ine |
| Description | Author Affiliation: Geers B ( Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium, Tel: +32 9 264 80 76) |
| Abstract | One of the main problems in cancer treatment is disease relapse through metastatic colonization, which is caused by circulating tumor cells (CTCs). This work reports on liposome-loaded microbubbles targeted to N-cadherin, a cell-cell adhesion molecule expressed by CTCs. It is shown that such microbubbles can indeed bind to N-cadherin at the surface of HMB2 cells. Interestingly, in a mixture of cells with and without N-cadherin expression, binding of the liposome-loaded microbubbles mainly occurs to the N-cadherin-expressing cells. Importantly, applying ultrasound results in the intracellular delivery of a model drug (loaded in the liposomes) in the N-cadherin-expressing cells only. As described in this paper, such liposome-loaded microbubbles may find application as theranostics and in devices aimed for the specific killing of CTCs in blood. |
| File Format | HTM / HTML |
| ISSN | 16136810 |
| Issue Number | 23 |
| Journal | Small |
| Volume Number | 9 |
| e-ISSN | 16136829 |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2013-12-09 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nanotechnology Cadherins Chemistry Drug Delivery Systems Methods Liposomes Microbubbles Humans Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology |
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