NDLI: Fluorescence-encoded gold nanoparticles: library design and modulation of cellular uptake into dendritic cells.

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Fluorescence-encoded gold nanoparticles: library design and modulation of cellular uptake into dendritic cells.

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Fluorescence-encoded gold nanoparticles: library design and modulation of cellular uptake into dendritic cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rodriguez-Lorenzo, Laura Fytianos, Kleanthis Blank, Fabian Von Garnier, Christophe Rothen-Rutishauser, Barbara Petri-Fink, Alke
Description	Author Affiliation: Rodriguez-Lorenzo L ( Adolphe Merkle Institute, University of Fribourg, Route de l'Ancienne Papeterie, P.O. Box 209, Marly 1723, (Switzerland).)
Abstract	In order to harness the unique properties of nanoparticles for novel clinical applications and to modulate their uptake into specific immune cells we designed a new library of homo- and hetero-functional fluorescence-encoded gold nanoparticles (Au-NPs) using different poly(vinyl alcohol) and poly(ethylene glycol)-based polymers for particle coating and stabilization. The encoded particles were fully characterized by UV-Vis and fluorescence spectroscopy, zeta potential and dynamic light scattering. The uptake by human monocyte derived dendritic cells in vitro was studied by confocal laser scanning microscopy and quantified by fluorescence-activated cell sorting and inductively coupled plasma atomic emission spectroscopy. We show how the chemical modification of particle surfaces, for instance by attaching fluorescent dyes, can conceal fundamental particle properties and modulate cellular uptake. In order to mask the influence of fluorescent dyes on cellular uptake while still exploiting its fluorescence for detection, we have created hetero-functionalized Au-NPs, which again show typical particle dependent cellular interactions. Our study clearly prove that the thorough characterization of nanoparticles at each modification step in the engineering process is absolutely essential and that it can be necessary to make substantial adjustments of the particles in order to obtain reliable cellular uptake data, which truly reflects particle properties.
File Format	HTM / HTML
ISSN	16136810
Issue Number	7
Volume Number	10
e-ISSN	16136829
Journal	Small
Language	English
Publisher	Wiley-VCH
Publisher Date	2014-04-09
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nanotechnology Dendritic Cells Metabolism Endocytosis Gold Chemistry Metal Nanoparticles Flow Cytometry Fluorescence Fluorescent Dyes Humans Ultrastructure Microscopy, Confocal Monocytes Cytology Particle Size Spectrophotometry, Atomic Static Electricity Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology

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