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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Fuyao He, Xiuxia Zhang, Junping Zhang, Huimao Wang, Zhenxin |
| Description | Author Affiliation: Liu F ( State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.); He X ( University of Chinese Academy of Sciences, Beijing, 100039, P. R. China.); Zhang J ( School of Life Science and Technology, Changchun University of Science and Technology, Changchun, 130022, P. R. China.); Zhang H ( School of Life Science and Technology, Changchun University of Science and Technology, Changchun, 130022, P. R. China.); Wang Z ( Department of Radiology Institution, The First Hospital of Jilin University, Changchun, 130021, P. R. China.) |
| Abstract | Hydrophobic ultrasmall nanoparticles synthesized in nonpolar solvents exhibit great potential in biomedical applications. However, a major challenge when applying these nanomaterials in biomedical research is the lack of a versatile strategy to render them water dispersible while preserving the hydrodynamic diameter (HD) to be less than 8 nm for efficient renal clearance. To address this problem, tryptone is employed as the novel ligand to fabricate a simple, versatile, and inexpensive strategy for transferring hydrophobic $NaGdF_{4}$ nanodots (3 nm in diameter) from organic phase into aqueous phase without any complicated organic synthesis. The paramagnetic properties of $NaGdF_{4}$ nanodots are well retained after the phase transfer process. In particular, the $tryptone–NaGdF_{4}$ nanodots have ultrasmall HD (ca., 7.5 nm), which greatly improves their tumor accumulation and facilitates renal clearance within 24 h postinjection. The as-prepared $tryptone–NaGdF_{4}$ nanodots can also be further functionalized with other molecules for extensively biomedical and bioanalytical applications. Furthermore, the proposed strategy can easily be extended to transfer other types of inorganic nanoparticles from hydrophobic to hydrophilic for facilitating biomedical applications. |
| File Format | HTM / HTML |
| ISSN | 16136810 |
| Issue Number | 30 |
| Volume Number | 11 |
| e-ISSN | 16136829 |
| Journal | Small |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2015-08-12 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nanotechnology Gadolinium Chemistry Kidney Metabolism Magnetic Resonance Imaging Methods Metal Nanoparticles Neoplasms, Experimental Pathology Peptones Pharmacokinetics Animals Contrast Media Chemical Synthesis Ultrastructure Mice Mice, Nude Phase Transition Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology |
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