NDLI: Prolonged Dye Release from Mesoporous Silica-Based Imaging Probes Facilitates Long-Term Optical Tracking of Cell Populations In Vivo.

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Prolonged Dye Release from Mesoporous Silica-Based Imaging Probes Facilitates Long-Term Optical Tracking of Cell Populations In Vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rosenholm, Jessica M. Gulin-Sarfraz, Tina Mamaeva, Veronika Niemi, Rasmus Özliseli, Ezgi Desai, Diti Antfolk, Daniel Von Haartman, Eva Lindberg, Desiré Prabhakar, Neeraj Näreoja, Tuomas Sahlgren, Cecilia
Description	Country affiliation: Finland Author Affiliation: Rosenholm JM ( Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, FI-20520, Turku, Finland.); Gulin-Sarfraz T ( Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, FI-20520, Turku, Finland.); Mamaeva V ( Laboratory of Physical Chemistry, Faculty of Science and Engineering, Åbo Akademi University, FI-20500, Turku, Finland.); Niemi R ( Department of Clinical Science, University of Bergen, Norway.); Özliseli E ( Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, P.O. Box 123, FI-20521, Turku, Finland.); Desai D ( Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, P.O. Box 123, FI-20521, Turku, Finland.); Antfolk D ( Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, FI-20520, Turku, Finland.); von Haartman E ( Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, FI-20520, Turku, Finland.); Lindberg D ( Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, FI-20520, Turku, Finland.); Prabhakar N ( Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, P.O. Box 123, FI-20521, Turku, Finland.); Näreoja T ( Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, FI-20520, Turku, Finland.); Sahlgren C ( Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, FI-20520, Turku, Finland.)
Abstract	Nanomedicine is gaining ground worldwide in therapy and diagnostics. Novel nanoscopic imaging probes serve as imaging tools for studying dynamic biological processes in vitro and in vivo. To allow detectability in the physiological environment, the nanostructure-based probes need to be either inherently detectable by biomedical imaging techniques, or serve as carriers for existing imaging agents. In this study, the potential of mesoporous silica nanoparticles carrying commercially available fluorochromes as self-regenerating cell labels for long-term cellular tracking is investigated. The particle surface is organically modified for enhanced cellular uptake, the fluorescence intensity of labeled cells is followed over time both in vitro and in vivo. The particles are not exocytosed and particles which escaped cells due to cell injury or death are degraded and no labeling of nontargeted cell populations are observed. The labeling efficiency is significantly improved as compared to that of quantum dots of similar emission wavelength. Labeled human breast cancer cells are xenotransplanted in nude mice, and the fluorescent cells can be detected in vivo for a period of 1 month. Moreover, ex vivo analysis reveals fluorescently labeled metastatic colonies in lymph node and rib, highlighting the capability of the developed probes for tracking of metastasis.
File Format	HTM / HTML
ISSN	16136810
Issue Number	12
Journal	Small
Volume Number	12
e-ISSN	16136829
Language	English
Publisher	Wiley-VCH
Publisher Date	2016-03-23
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Medicine Biomaterials Engineering Biotechnology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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