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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Seeliger, Katharina Dukowic-Schulze, Stefanie Wurz-Wildersinn, Rebecca Pacher, Michael Puchta, Holger |
| Description | Country affiliation: Germany Author Affiliation: Seeliger K ( Botanical Institute II, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.) |
| Abstract | ⢠Mutations in the breast cancer susceptibility gene 2 (BRCA2) are correlated with hereditary breast cancer in humans. Studies have revealed that mammalian BRCA2 plays crucial roles in DNA repair. Therefore, we wished to define the role of the BRCA2 homologs in Arabidopsis in detail. ⢠As Arabidopsis contains two functional BRCA2 homologs, an Atbrca2 double mutant was generated and analyzed with respect to hypersensitivity to genotoxic agents and recombination frequencies. Cytological studies addressing male and female meiosis were also conducted, and immunolocalization was performed in male meiotic prophase I. ⢠The Atbrca2 double mutant showed hypersensitivity to the cross-linking agent mitomycin C and displayed a dramatic reduction in somatic homologous recombination frequency, especially after double-strand break induction. The loss of AtBRCA2 also led to severe defects in male meiosis and development of the female gametophyte and impeded proper localization of the synaptonemal complex protein AtZYP1 and the recombinases AtRAD51 and AtDMC1. ⢠The results demonstrate that AtBRCA2 is important for both somatic and meiotic homologous recombination. We further show that AtBRCA2 is required for proper meiotic synapsis and mediates the recruitment of AtRAD51 and AtDMC1. Our results suggest that BRCA2 controls single-strand invasion steps during homologous recombination in plants. |
| File Format | HTM / HTML |
| ISSN | 0028646X |
| Issue Number | 2 |
| Volume Number | 193 |
| e-ISSN | 14698137 |
| Journal | New Phytologist |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Botany Arabidopsis Proteins Metabolism Arabidopsis Genetics Brca2 Protein Cell Cycle Proteins Homologous Recombination Rad51 Recombinase Rec A Recombinases Cytology Embryology Base Sequence Chromosome Segregation Drug Effects Dna, Bacterial Genes, Plant Meiosis Mitomycin Pharmacology Molecular Sequence Data Mutagenesis, Insertional Mutation Mutation Rate Ovule Growth & Development Plant Infertility Pollen Seeds Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Plant Science |
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