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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Beltran, Antoni Marcé, Rosa M. Cormack, Peter A. G. Sherrington, David C. Borrull, Francesc |
| Description | Country affiliation: Spain Author Affiliation: Beltran A ( Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Tarragona, Spain.) |
| Abstract | In this paper we describe, for the first time, a molecularly imprinted polymer (MIP) for the antibiotic amoxicillin (AMX), synthesised by a noncovalent molecular imprinting approach and used to extract AMX selectively from urine samples. The MIP was applied as a molecularly selective sorbent in molecularly imprinted SPE (MISPE) in an off-line mode, where it showed useful cross-selectivity for a structurally related antibiotic, cephalexin (CPX). By using a MISPE protocol, the MIP was able to selectively extract both AMX and CFX from 5 mL of water spiked with 10 mg/L with recoveries of 75 and 78% for AMX and CFX, respectively. When applied to real samples (urine) at clinically relevant concentrations, recoveries from 2 mL of human urine spiked with 20 mg/L decreased slightly to 65 and 63% for AMX and CFX, respectively. To demonstrate further the selectivity of the MIP obtained, a comparison with commercially available SPE cartridges was performed. Improvements in the retention of both AMX and CFX on the MIP were obtained relative to the commercially available cartridges, and the MISPE extracts were considerably cleaner, due to molecularly selective analyte binding by the MIP. |
| File Format | HTM / HTML |
| ISSN | 16159306 |
| Issue Number | 15 |
| Volume Number | 31 |
| e-ISSN | 16159314 |
| Journal | Journal of Separation Science |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2008-08-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Amoxicillin Urine Cephalexin Molecular Imprinting Methods Polymers Chemistry Solid Phase Extraction Instrumentation Humans Hydrogen-ion Concentration Molecular Conformation Chemical Synthesis Reference Values Reproducibility Of Results Sensitivity And Specificity Stereoisomerism Time Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry Filtration and Separation |
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