NDLI: Hydrophilic interaction chromatography-tandem mass spectrometric analysis of irbesartan in human plasma: application to pharmacokinetic study of irbesartan.

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Hydrophilic interaction chromatography-tandem mass spectrometric analysis of irbesartan in human plasma: application to pharmacokinetic study of irbesartan.

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Hydrophilic interaction chromatography-tandem mass spectrometric analysis of irbesartan in human plasma: application to pharmacokinetic study of irbesartan.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, Hye Won Ji, Hye Young Park, Eun-Seok Lee, Kang Choon Lee, Hye Suk
Description	Author Affiliation: Lee HW ( Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy and Phytofermentation Research Center, Wonkwang University, Iksan, Korea.)
Abstract	A hydrophilic interaction chromatography-tandem mass spectrometric method (HILIC/MS/MS) for the determination of irbesartan in human plasma was developed. Irbesartan and losartan (internal standard) were extracted from human plasma with ethyl acetate at acidic pH. The analytes were analyzed on a Luna HILIC column with the mobile phase of ACN-ammonium formate (50 mM, pH 6.5) (96:4, v/v) and detected by ESI MS/MS in the selected reaction monitoring mode. The standard curve was linear (r(2) = 0.9981) over the concentration range of 10-2500 ng/mL and the lower LOQ was 10 ng/mL using 100 microL of plasma sample. The CV and relative error for intra- and interassay at four QC levels were 2.9 to 8.1% and -2.7 to 2.3%, respectively. There were less absolute and relative matrix effects for irbesartan and losartan. The present method was successfully applied to the pharmacokinetic study of irbesartan after oral dose of irbesartan (150 mg tablet) to male healthy volunteers.
File Format	HTM / HTML
ISSN	16159306
Issue Number	14
Volume Number	32
e-ISSN	16159314
Journal	Journal of Separation Science
Language	English
Publisher	Wiley-VCH
Publisher Date	2009-07-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Discipline Chemistry Biphenyl Compounds Blood Pharmacokinetics Chromatography, Liquid Methods Tandem Mass Spectrometry Tetrazoles Administration, Oral Administration & Dosage Calibration Humans Linear Models Losartan Male Reference Values Spectrometry, Mass, Electrospray Ionization Time Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Filtration and Separation

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