NDLI: Ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight mass spectrometry for rapid analysis of constituents of Suanzaoren decoction.

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Ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight mass spectrometry for rapid analysis of constituents of Suanzaoren decoction.

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Ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight mass spectrometry for rapid analysis of constituents of Suanzaoren decoction.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Bo Dong, Wei Zhang, Aihua Sun, Hui Wu, Fangfang Wang, Ping Wang, Xijun
Description	Author Affiliation: Yang B ( National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin, PR China.)
Abstract	A rapid, sensitive, specific and reliable ultra-performance liquid chromatography coupled with electrospray ionization/quadrupole-time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS) method with MassLynx™ MassFragment was developed for the analysis of Suanzaoren decoction (SZRD), a Chinese herbal prescription. The analysis was performed on a Waters UPLC BEH C(18) column using gradient elution system. A hyphenated electrospray ionization and Q-TOF analyzer was used for the determination of accurate mass of the protonated or deprotonated molecule and fragment ion in both negative and positive modes. The chromatographic separation was achieved by UPLC, which used a column with 1.7 µm particle packing which enabled higher speed of analysis, peak capacity, greater resolution and increased sensitivity. The constituents of SZRD were identied and confirmed according to the mass spectrometric fragmentation mechanisms, MS/MS fragment ions, relevant literature and the establishment of an in-house molecular formula database. With this method, a total of 22 compounds of SZTD were tentatively identied based on MS and MS/MS data and comparison with available databases. It is concluded that a rapid and robust platform based on UPLC-ESI-Q-TOF-MS was established, which is useful for identifying multiple-constituent of traditional Chinese medicine (TCM) prescriptions. Our present results proved that the established method could provide helpful chemical information for further pharmacological mechanism research of SZRD.
File Format	HTM / HTML
ISSN	16159306
Issue Number	22
Journal	Journal of Separation Science
Volume Number	34
e-ISSN	16159314
Language	English
Publisher	Wiley-VCH
Publisher Date	2011-11-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Discipline Chemistry Drugs, Chinese Herbal Analysis Tandem Mass Spectrometry Methods Chromatography, High Pressure Liquid Spectrometry, Mass, Electrospray Ionization Evaluation Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Filtration and Separation

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