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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Goudarzi, Nasser Farsimadan, Sahar Chamjangali, Mansour Arab Bagherian, Ghadam Ali |
| Description | Country affiliation: Iran Author Affiliation: Goudarzi N ( Faculty of chemistry, University of Shahrood, Shahrood, Iran.); Farsimadan S ( Faculty of chemistry, University of Shahrood, Shahrood, Iran.); Chamjangali MA ( Faculty of chemistry, University of Shahrood, Shahrood, Iran.); Bagherian GA ( Faculty of chemistry, University of Shahrood, Shahrood, Iran.) |
| Abstract | A simple, sensitive, and rapid microextraction method, namely, ultrasound-assisted surfactant-enhanced emulsification microextraction based on the solidification of floating organic droplet method coupled with high-performance liquid chromatography was developed for the simultaneous preconcentration and determination of nitrazepam and midazolam. The significant parameters affecting the extraction efficiency were considered using Plackett-Burman design as a screening method. To obtain the optimum conditions with consideration of the selected significant variables, a Box-Behnken design was used. The microextraction procedure was performed using 29.1 µL of 1-undecanol, 1.36% (w/v) of NaCl, 10.0 µL of sodium dodecyl sulfate (25.0 µg mL(-1)), and 1.0 µL of Tween80 (25.0 µg mL(-1)) as an emulsifier in an extraction time of 20.0 min at pH 7.88. In order to investigate the validation of the developed method, some validation parameters including the linear dynamic range, repeatability, limit of detection, and recoveries were studied under the optimum conditions. The detection limits of the method were 0.017 and 0.086 ng mL(-1) for nitrazepam and midazolam, respectively. The extraction recovery percentages for the drugs studied were above 91.0 with acceptable relative standard deviation. The proposed methodology was successfully applied for the determination of these drugs in a number of human serum samples. |
| File Format | HTM / HTML |
| ISSN | 16159306 |
| Issue Number | 10 |
| Volume Number | 38 |
| e-ISSN | 16159314 |
| Journal | Journal of Separation Science |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2015-05-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Chromatography, High Pressure Liquid Methods Hypnotics And Sedatives Blood Liquid Phase Microextraction Midazolam Nitrazepam Humans Journal Article Validation Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry Filtration and Separation |
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