NDLI: Comparative evaluation of a one-pot strategy for the preparation of ß-cyclodextrin-functionalized monoliths: Effect of the degree of amino substitution of ß-cyclodextrin on the column performance.

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Comparative evaluation of a one-pot strategy for the preparation of ß-cyclodextrin-functionalized monoliths: Effect of the degree of amino substitution of ß-cyclodextrin on the column performance.

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Comparative evaluation of a one-pot strategy for the preparation of ß-cyclodextrin-functionalized monoliths: Effect of the degree of amino substitution of ß-cyclodextrin on the column performance.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Qiaoxuan Guo, Jialiang Xiao, Yuan Crommen, Jacques Jiang, Zhengjin
Description	Country affiliation: China Author Affiliation: Zhang Q ( Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou, China.); Guo J ( Department of Laboratory Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.); Xiao Y ( Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou, China.); Crommen J ( Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou, China.); Jiang Z ( Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou, China.)
Abstract	To further evaluate the feasibility and applicability of the one-pot strategy in monolithic column preparation, two novel ß-cyclodextrin-functionalized organic polymeric monoliths were prepared using two ß-cyclodextrin derivatives, i.e. mono(6-amino-6-deoxy)-ß-cyclodextrin and heptakis(6-amino-6-deoxy)-ß-cyclodextrin. In this improved method, mono(6-amino-6-deoxy)-ß-cyclodextrin or heptakis(6-amino-6-deoxy)-ß-cyclodextrin reacted with glycidyl methacrylate to generate the corresponding functional monomers and were subsequently copolymerized with ethylene dimethacrylate. The polymerization conditions for both monoliths were carefully optimized to obtain satisfactory column performance with respect to column efficiency, reproducibility, permeability, and stability. The obtained poly(glycidyl methacrylate-mono(6-amino-6-deoxy)-ß-cyclodextrin-co-ethylene dimethacrylate) and poly(glycidyl methacrylate-heptakis(6-amino-6-deoxy)-ß-cyclodextrin-co-ethylene dimethacrylate) monoliths exhibited a uniform structure, good permeability, and mechanical stability as indicated by scanning electron microscopy and micro-high-performance liquid chromatography experimental results. Because of the probable existence of multi-glycidyl methacrylate linking spacers on the poly(glycidyl methacrylate-heptakis(6-amino-6-deoxy)-ß-cyclodextrin-co-ethylene dimethacrylate) monolith, the effect of the ratio of glycidyl methacrylate/heptakis(6-amino-6-deoxy)-ß-cyclodextrin was especially studied, and satisfactory reproducibility could still be achieved by strictly controlling the composition of the polymerization mixture. To investigate the effect of the degree of amino substitution of ß-cyclodextrin on column performance, a detailed comparison of the two monoliths was also carried out using series of analytes including small peptides and chiral acids. It was found that the ß-cyclodextrin-functionalized monolith with mono-glycidyl methacrylate linking spacers demonstrated better chiral separation performance than that with multi-glycidyl methacrylate linking spacers.
File Format	HTM / HTML
ISSN	16159306
Issue Number	11
Volume Number	38
e-ISSN	16159314
Journal	Journal of Separation Science
Language	English
Publisher	Wiley-VCH
Publisher Date	2015-06-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Discipline Chemistry Amines Chemistry Chromatography, High Pressure Liquid Instrumentation Beta-cyclodextrins Microscopy, Electron, Scanning Permeability Polymerization Reproducibility Of Results Stereoisomerism Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Filtration and Separation

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Preparation of a permethylated ß-cyclodextrin chiral stationary phase by one-pot hydrosilylation and immobilization at the C2 position for chiral high-performance liquid chromatography.

Chiral ß-cyclodextrin functionalized polymer monolith for the direct enantioselective reversed phase nano liquid chromatographic separation of racemic pharmaceuticals.

Preparation of monomeric and polymeric ß-cyclodextrin functionalized monoliths for rapid isolation and purification of puerarin from Radix puerariae.

A facile and efficient one-step strategy for the preparation of ß-cyclodextrin monoliths.

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Enantiomeric separation of oxybutynin by recycling high-speed counter-current chromatography with hydroxypropyl-ß-cyclodextrin as chiral selector.

Effect of the crosslinker type on the enantioseparation performance of ß-cyclodextrin functionalized monoliths prepared by the one-pot approach.

Cyclodextrin-modified MEKC for enantioseparation of hexaconazole, penconazole, and myclobutanil.

Comparative evaluation of a one-pot strategy for the preparation of ß-cyclodextrin-functionalized monoliths: Effect of the degree of amino substitution of ß-cyclodextrin on the column performance.

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