NDLI: Bisphosphonate-related osteonecrosis of the jaw associated with dental implants.

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Bisphosphonate-related osteonecrosis of the jaw associated with dental implants.

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Bisphosphonate-related osteonecrosis of the jaw associated with dental implants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lazarovici, Towy Sorel Yahalom, Ran Taicher, Shlomo Schwartz-Arad, Devorah Peleg, Oren Yarom, Noam
Description	Country affiliation: Israel Author Affiliation: Lazarovici TS ( Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel Hashomer, Israel. towy_lazarovici@yahoo.com)
Abstract	PURPOSE: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a well-documented devastating side effect of long-term bisphosphonate (BP) use. There is scarce information in the literature on BRONJ associated with dental implants (DIs). The purpose of this study was to present a large series of cases of this association. PATIENTS AND METHODS: The files of all patients with BRONJ associated with DIs who were treated in the department of oral and maxillofacial surgery from 2003 to 2009 were reviewed. Data on demographics, medical background, type, and duration of BP treatment before the development of BRONJ, mode of therapy, and therapeutic outcome were retrieved. RESULTS: Of the 27 patients enrolled into the study, 11 (41%) developed BRONJ while taking oral BPs and 16 (59%) developed BRONJ associated with intravenous BPs. BRONJ developed after mean periods of 68 months (median, 60), 16.4 months (median, 13), and 50.2 months (median, 35) in patients on alendronate, zoledronic acid, and pamidronate, respectively. Only 6 patients developed BRONJ during the first 6 months after DI placement. When BP treatment had been started before DI placement, there was a mean duration of 16.2 months (median, 11) until the appearance of BRONJ development. Long-term antibiotics and only essential surgical procedures comprised the treatment of choice, and the response rate was considerably better for patients taking the oral type of BPs. There was no significant association between BRONJ and diabetes, steroid intake, or smoking habits. CONCLUSION: Patients undergoing BP treatment and who receive DIs require a prolonged follow-up period to detect any development of BRONJ associated with DIs.
File Format	HTM / HTML
ISSN	02782391
Issue Number	4
Volume Number	68
e-ISSN	15315053
Journal	Journal of Oral and Maxillofacial Surgery
Language	English
Publisher	Elsevier
Publisher Date	2010-04-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medicine__semicolon__otorhinolaryngology__semicolon__surgery Bone Density Conservation Agents Adverse Effects Dental Implantation, Endosseous Dental Implants Diphosphonates Jaw Diseases Etiology Osteonecrosis Administration, Oral Aged Anti-bacterial Agents Therapeutic Use Administration & Dosage Device Removal Doxycycline Female Humans Injections, Intravenous Drug Therapy Male Middle Aged Retrospective Studies Treatment Outcome Journal Article
Content Type	Text
Resource Type	Article
Subject	Oral Surgery Otorhinolaryngology Surgery

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