NDLI: Cytotoxic and apoptotic activity of Cheilanthes farinosa (Forsk.) Kaulf. against human hepatoma, Hep3B cells.

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Cytotoxic and apoptotic activity of Cheilanthes farinosa (Forsk.) Kaulf. against human hepatoma, Hep3B cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Radhika, N. Krishna Sreejith, P. S. Asha, V. V.
Description	Country affiliation: India Author Affiliation: Radhika NK ( Bioprospecting and Molecular Pharmacology Laboratory, Division of Molecular Medicine and Cancer Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala 695014, India.)
Abstract	AIM OF THE STUDY: Cheilanthes farinosa (Forsk.) Kaulf., family: Adianthaceae, is a fern of immense medicinal properties used in ethno-medicine. The Gaddis tribe of Himachal Pradesh, India, has been using this fern to treat liver damage. Aim of the current study was to determine the apoptosis inducing and cytotoxic activity, if any, of this fern towards hepatic cancer cells. MATERIALS AND METHODS: Water extract of the plant was used in the study. MTT assay was performed in hepatocellular carcinoma cell line, Hep3B as well as murine macrophage cell line, RAW264.7 to analyze the cytotoxic activity of the plant. Further, the apoptosis inducing action of water extract of the plant was evaluated using comet assay, DNA fragmentation analysis, DAPI staining of chromatin and Annexin V-FITC staining. RESULTS: This plant was found to produce considerable cytotoxicity in hepatoma cell line, Hep3B without inducing substantial damage to non-cancerous cell line RAW264.7. In addition, this plant was found to induce apoptosis in Hep3B cells. This was substantiated by comet assay, DNA fragmentation analysis, DAPI staining of chromatin and Annexin V-FITC staining for detecting early stage of apoptosis. CONCLUSIONS: This investigation shows that the water extract of Cheilanthes farinosa has antiproliferative and apoptotic activity in human liver cancer cells and is not deleterious towards non-cancerous macrophage cell line.
File Format	HTM / HTML
ISSN	03788741
Issue Number	1
Volume Number	128
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2010-03-02
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Antineoplastic Agents Pharmacology Apoptosis Drug Effects Carcinoma, Hepatocellular Pathology Liver Neoplasms Plant Extracts Pteridaceae Chemistry Animals Cell Line Cell Line, Tumor Comet Assay Drug Screening Assays, Antitumor Humans Mice Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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