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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jin, Song Nan Wen, Jin Fu Kim, Hye Yoom Kang, Dae Gill Lee, Ho Sub Cho, Kyung Woo |
| Description | Country affiliation: China Author Affiliation: Jin SN ( Institute of Materia Medica, Taishan Medical University, Middle of Changcheng Road, Taian, Shandong 271016, China. snjin0504@yahoo.com.cn) |
| Abstract | AIM OF THE STUDY: The aim of the present study was to define the effect of Xanthoceras sorbifolia extracts (XS) on vascular tension and responsible mechanisms in rat thoracic aortic rings. MATERIALS AND METHODS: Ethanol extract of the leaves of XS (EXS) was examined for their vascular relaxant effects in isolated phenylephrine-precontracted rat thoracic aorta. RESULTS: EXS (0.1-100 µg/ml) induced relaxation of the phenylephrine-precontracted aortic rings in a concentration-dependent manner. Endothelium-denudation abolished EXS-induced vasorelaxation. Pretreatment of the endothelium-intact aortic rings with N(G)-nitro-L-arginine methylester (L-NAME) and 1H-[1,2,4]-oxadiazolo-[4,3- ]-quinoxalin-1-one (ODQ) inhibited EXS-induced vasorelaxation. Inhibition of Ca(2+) entry via L-type Ca(2+) channels failed to block the EXS-induced vasorelaxation. Extracellular Ca(2+) depletion significantly attenuated EXS-induced vasorelaxation. Modulators of the store-operated Ca(2+) entry (SOCE), thapsigargin, 2-aminoethyl diphenylborinate (2-APB) and Gd(3+), and an inhibitor of Akt, wortmannin, markedly attenuated the EXS-induced vasorelaxation. EXS increased cGMP levels of the aortic rings in a concentration-dependent manner and the effect was blocked by L-NAME, ODQ, thapsigargin, Gd(3+), 2-APB, and wortmannin. Further, EXS-induced vasorelaxation was significantly attenuated by tetraethylammonium, a non-selective K(ca) channels blocker, but not by glibenclamide, an ATP-sensitive K(+) channels inhibitor. Inhibition of cyclooxygenase with indomethacin, and adrenergic and muscarinic receptors blockade had no effects on EXS-induced vasorelaxation. CONCLUSIONS: The present study suggests that EXS relaxes vascular smooth muscle via endothelium-dependent NO-cGMP signaling through activation of the Akt- and SOCE-eNOS-sGC pathways, which may, at least in part, be related to the function of K(+) channels. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 1 |
| Volume Number | 132 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-10-28 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Calcium Metabolism Cyclic Gmp Drugs, Chinese Herbal Pharmacology Nitric Oxide Synthase Type Iii Proto-oncogene Proteins C-akt Sapindaceae Chemistry Vasodilation Drug Effects Vasodilator Agents Animals Aorta, Thoracic Enzymology Isolation & Purification Endothelium, Vascular Ethanol In Vitro Techniques Male Muscle, Smooth, Vascular Nitric Oxide Biosynthesis Plant Leaves Potassium Channels Rats Rats, Sprague-dawley Signal Transduction Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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