NDLI: Anticonvulsant activity of aqueous root extract of Ficus religiosa.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Patil, Minal S. Patil, C. R. Patil, S. W. Jadhav, R. B.
Spatial Coverage	India
Description	Country affiliation: India Author Affiliation: Patil MS ( Department of Pharmacognosy, RC Patel Institute of Pharmaceutical Education & Research, Shirpur, Maharashtra, India.)
Abstract	ETHNOPHARMACOLOGICAL RELEVANCE: Ficus religiosa Linn is frequently used for the treatment of nervous disorders among Pawara tribe of the Satpuda range, India. AIM OF THE STUDY: This study aimed to investigate the anticonvulsant activity of the aqueous aerial root extract of Ficus religiosa in chemoconvulsant-induced seizures in mice. MATERIALS AND METHODS: The anticonvulsant activity of the extract (25, 50 and 100 mg/kg, p.o.) was investigated in strychnine-, pentylenetetrazole-, picrotoxin- and isoniazid-induced seizures in mice. Rat ileum and fundus strip preparations were used to study the effect of the extract on acetylcholine (Ach)- and serotonin (5-HT)-induced contractions, respectively. RESULTS: The extract showed no toxicity and protected the animals in the strychnine and pentylenetetrazole tests in a dose-dependent manner. Its effect in the picrotoxin and isoniazid tests, however, was less potent. The extract also exhibited dose-dependent potentiation of Ach in rat ileum but failed to potentiate the effect of 5-HT in rat fundus strip preparation. CONCLUSIONS: The results suggest that an orally administered aqueous root extract of Ficus religiosa has dose-dependent and potent anticonvulsant activities against strychnine- and pentylenetetrazole-induced seizures. The observed activities may be ascribed to the appreciable content of zinc and magnesium in the extract.
File Format	HTM / HTML
ISSN	03788741
Issue Number	1
Volume Number	133
e-ISSN	18727573
Journal	Journal of Ethnopharmacology
Language	English
Publisher	Elsevier
Publisher Date	2011-01-07
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ethnopharmacology Anticonvulsants Pharmacology Ficus Phytotherapy Seizures Drug Therapy Prevention & Control Amino Acids Analysis Animals Toxicity Dose-response Relationship, Drug Drug Evaluation, Preclinical India Male Mice Plant Extracts Chemistry Plant Roots Rats Rats, Wistar Chemically Induced Journal Article
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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