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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Park, Hye-Jin Zhang, Nannan Park, Dong Ki |
| Description | Author Affiliation: Park HJ ( Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul 143-701, Republic of Korea. hyejinpak@gmail.com) |
| Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Polygonum multiflorum has traditionally been used for treating patients suffering from baldness and hair loss in East Asia. AIM OF THE STUDY: The present study sought to investigate the hair growth promoting activities of Polygonum multiflorum and its mechanism of action. MATERIALS AND METHODS: The Polygonum multiflorum extract was topically applied to the shaved dorsal skin of telogenic C57BL6/N mice. To determine the effect of Polygonum multiflorum extract in telogen to anagen transition, the expression of ß-catenin and Sonic hedgehog (Shh) was determined by immunohistochemistry analysis. RESULTS: Polygonum multiflorum extract promoted hair growth by inducing anagen phase in telogenic C57BL6/N mice. In Polygonum multiflorum extract treated group, we observed increase in the number and the size of hair follicles that are considered as evidence for anagen phase induction. Immunohistochemical analysis revealed that earlier induction of ß-catenin and Shh were observed in Polygonum multiflorum extract treated group compared to that in control group. CONCLUSION: These results suggest that Polygonum multiflorum extract promotes hair growth by inducing anagen phase in resting hair follicles. |
| File Format | HTM / HTML |
| ISSN | 03788741 |
| Issue Number | 2 |
| Volume Number | 135 |
| e-ISSN | 18727573 |
| Journal | Journal of Ethnopharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-05-17 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ethnopharmacology Hair Drug Effects Hedgehog Proteins Metabolism Plant Extracts Pharmacology Polygonum Chemistry Up-regulation Beta Catenin Administration, Topical Animals Growth & Development Immunohistochemistry Mice Mice, Inbred C57bl Administration & Dosage Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology |
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