NDLI: Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Symons, T. B. Sheffield-Moore, M. Chinkes, D. L. Ferrando, A. A. Paddon-Jones, D.
Description	Country affiliation: United States Author Affiliation: Symons TB ( The Univ. of Texas Medical Branch, 301 Univ. Blvd., Galveston, TX 77555-1144, USA.)
Abstract	We sought to determine the effects of longitudinal loading (artificial gravity) on skeletal muscle protein kinetics in 15 healthy young males after 21 days of 6 degrees head-down tilt bed rest [experimental treatment (Exp) group: n = 8, 31 +/- 1 yr; control (Con) group; n = 7, 28 +/- 1 yr, means +/- SE]. On days 1 and 21 of bed rest, postabsorptive venous blood samples and muscle biopsies (vastus lateralis and soleus) were obtained during a 1-h pulse bolus infusion protocol (0 min, l-[ring-(13)C(6)]phenylalanine, 35 mumol/kg; 30 min, l-[ring-(15)N]phenylalanine, 35 mumol/kg). Outcome measures included mixed muscle fractional synthesis (FSR) and breakdown rates (FBR). The Exp group experienced 1 h of longitudinal loading (2.5G at the feet) via a short-radius centrifuge during each day of bed rest. Mixed muscle FSR in the Con group was reduced by 48.5% (day 1, 0.081 +/- 0.000%/h vs. day 21, 0.042 +/- 0.000%/h; P = 0.001) in vastus lateralis after 21 days of bed rest, whereas the Exp group maintained their rate of protein synthesis. A similar but nonsignificant change in FSR was noted for the soleus muscle (Exp, -7%; Con, -22%). No changes in muscle protein breakdown were observed. In conclusion, 1 h of daily exposure to artificial gravity maintained the rate of protein synthesis of the vastus lateralis and may represent an effective adjunct countermeasure to combat the loss of muscle mass and functional during extended spaceflight.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
DOI	10.1152/japplphysiol.91137.2008
Journal	Journal of Applied Physiology
Issue Number	1
Volume Number	107
Language	English
Publisher	American Physiological Society
Publisher Date	2009-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Gravity, Altered Muscle Proteins Biosynthesis Muscle, Skeletal Metabolism Muscular Atrophy Prevention & Control Muscular Disorders, Atrophic Weightlessness Countermeasures Bed Rest Adverse Effects Head-down Tilt Etiology Weight-bearing Physiology Weightlessness Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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