NDLI: Skeletal muscle structural and energetic characteristics in subjects with sickle cell trait, alpha-thalassemia, or dual hemoglobinopathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vincent, Lucile Féasson, Léonard Oyono-Enguéllé, Samuel Banimbek, Viviane Monchanin, Géraldine Dohbobga, Macias Wouassi, Dieudonné Martin, Cyril Gozal, David Geyssant, André Thiriet, Patrice Denis, Christian Messonnier, Laurent
Spatial Coverage	Cameroon
Description	Country affiliation: France Author Affiliation: Vincent L ( Laboratoire de Physiologie de l'Exercice EA4338, Université de Savoie, Chambéry, France.)
Abstract	Previous studies have shown that subjects with sickle cell trait (SCT), alpha-thalassemia (alpha-t), and the dual hemoglobinopathy (SCT/alpha-t) manifest subtle, albeit significant, differences during exercise. To better understand such differences, we assessed skeletal muscle histomorphological and energetic characteristics in 10 control HbAA subjects (C), 5 subjects with alpha-t (alpha-t), 6 SCT carriers (SCT) and 9 SCT carriers with alpha-t (SCT/alpha-t). Subjects underwent a muscle biopsy and also performed an incremental maximal exercise and a time to exhaustion test. There were no observable differences in daily energy expenditure, maximal power output (Pmax), or time to exhaustion at 110% Pmax (Tex) among the groups. Blood lactate concentrations measured at the end of the Tex, muscle fiber type distribution, and mean phosphofructokinase (PFK), lactate dehydrogenase (LDH), beta-hydroxyacyl-CoA-dehydrogenase (HAD), and citrate synthase (CS) activities were all similar among the four groups. However, SCT was associated with a lower cytochrome-c oxidase (COx) activity in type IIa fibers (P<0.05), and similar trends were observed in fiber types I and IIx. Trends toward lower creatine kinase (CK) activity (P=0.0702) and higher surface area of type IIx fibers were observed in SCT (P=0.0925). In summary, these findings support most of the previous observations in SCT, such as 1) similar maximal power output and associated maximal oxygen consumption (VO2max) values and 2) lower exercise performances during prolonged submaximal exercise. Furthermore, performances during short supramaximal exercise were not different in SCT. Finally, the dual hemoglobinopathy condition does not seem to affect muscle characteristics.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	3
Volume Number	109
Language	English
Publisher	American Physiological Society
Publisher Date	2010-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Energy Metabolism Exercise Tolerance Muscle, Skeletal Enzymology Physiopathology Sickle Cell Trait Alpha-thalassemia Biological Markers Blood Biopsy Cameroon Hemoglobin A, Glycosylated Metabolism Hemoglobins, Abnormal Lactic Acid Muscle Strength Pathology Oxygen Consumption Genetics Time Factors Comparative Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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