NDLI: Endurance training-induced accumulation of muscle triglycerides is coupled to upregulation of stearoyl-CoA desaturase 1.

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Point: Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension.

Heat stroke: role of the systemic inflammatory response.

Twelve weeks of endurance training increases FFA mobilization and reesterification in postmenopausal women.

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Vestibular-mediated increase in central serotonin plays an important role in hypergravity-induced hypophagia in rats.

Endurance training-induced accumulation of muscle triglycerides is coupled to upregulation of stearoyl-CoA desaturase 1.

In search of complexity.

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Effects of cross-education on the muscle after a period of unilateral limb immobilization using a shoulder sling and swathe.

Counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension.

Rebuttal from Esler, Lambert, and Schlaich.

Rebuttal from Navar.

Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activated intrarenal renin-angiotensin system is correlated with high blood pressure in humans.

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Endurance training-induced accumulation of muscle triglycerides is coupled to upregulation of stearoyl-CoA desaturase 1.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dobrzyn, Pawel Pyrkowska, Aleksandra Jazurek, Magdalena Szymanski, Konrad Langfort, Jozef Dobrzyn, Agnieszka
Description	Country affiliation: Poland Author Affiliation: Dobrzyn P ( Laboratory of Cell Signaling and Metabolic Disorders, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland. adobrzyn@nencki.gov.pl)
Abstract	Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids, has recently been shown to be a critical control point in regulation of liver and skeletal muscle metabolism. Herein, we demonstrate that endurance training significantly increases both SCD1 mRNA and protein levels in the soleus muscle, whereas it does not affect SCD1 expression in the EDL muscle and liver. Desaturation index (18:1Δ9/18:0 ratio), an indirect indicator of SCD1 activity, was also significantly higher (3.6-fold) in soleus of trained rats compared with untrained animals. Consistent with greater SCD1 expression/activity, the contents of free fatty acids, diacylglycerol, and triglyceride were elevated in soleus of trained rats. However, training did not affect lipid concentration in EDL and liver. Additionally, endurance training activated the AMP-activated protein kinase pathway as well as increased peroxisome proliferator-activated receptor (PPAR)-Î´ and PPAR gene expression and activity in soleus and liver. Increased lipid accumulation in soleus was coupled with elevated protein levels of fatty acid synthase, mRNA levels of diacylglycerol acyltransferase and glycerol-3-phosphate transferase, as well as increased levels of proteins involved in fatty acid transport (fatty acid translocase/CD36, fatty acid transport protein 1). Interestingly, sterol regulatory element-binding protein (SREBP)-1c expression and SREBP-1 protein levels were not affected by exercise training. Together, the obtained data suggest that SCD1 upregulation plays an important role in adaptation of oxidative muscle to endurance training.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	6
Volume Number	109
Language	English
Publisher	American Physiological Society
Publisher Date	2010-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Muscle Contraction Muscle, Skeletal Enzymology Physical Endurance Stearoyl-coa Desaturase Metabolism Triglycerides Amp-activated Protein Kinases Acetyl-coa Carboxylase Adaptation, Physiological Animals Antigens, Cd95 Biological Transport Fatty Acids Gene Expression Regulation, Enzymologic Lipid Metabolism Genetics Liver Oxidation-reduction Ppar Delta Phosphorylation Rna, Messenger Rats, Wistar Up-regulation Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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