NDLI: Changes in lower extremity muscle function after 56 days of bed rest.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Buehring, B. Belavy, D. L. Michaelis, I. Gast, U. Felsenberg, D. Rittweger, J.
Spatial Coverage	Germany
Description	Country affiliation: Germany Author Affiliation: Buehring B ( Center for Muscle and Bone Research, Charité Universitätsmedizin Berlin, Free and Humboldt Universities, Berlin, Germany.)
Abstract	Preservation of muscle function, known to decline in microgravity and simulation (bed rest), is important for successful spaceflight missions. Hence, there is great interest in developing interventions to prevent muscle-function loss. In this study, 20 males underwent 56 days of bed rest. Ten volunteers were randomized to do resistive vibration exercise (RVE). The other 10 served as controls. RVE consisted of muscle contractions against resistance and concurrent whole-body vibration. Main outcome parameters were maximal isometric plantar-flexion force (IPFF), electromyography (EMG)/force ratio, as well as jumping power and height. Measurements were obtained before and after bed rest, including a morning and evening assessment on the first day of recovery from bed rest. IPFF (-17.1%), jumping peak power (-24.1%), and height (-28.5%) declined (P < 0.05) in the control group. There was a trend to EMG/force ratio decrease (-20%; P = 0.051). RVE preserved IPFF and mitigated the decline of countermovement jump performance (peak power -12.2%; height -14.2%). In both groups, IPFF was reduced between the two measurements of the first day of reambulation. This study indicates that bed rest and countermeasure exercises differentially affect the various functions of skeletal muscle. Moreover, the time course during recovery needs to be considered more thoroughly in future studies, as IPFF declined not only with bed rest but also within the first day of reambulation. RVE was effective in maintaining IPFF but only mitigated the decline in jumping performance. More research is needed to develop countermeasures that maintain muscle strength as well as other muscle functions including power.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
Journal	Journal of Applied Physiology
Issue Number	1
Volume Number	111
Language	English
Publisher	American Physiological Society
Publisher Date	2011-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Bed Rest Adverse Effects Isometric Contraction Muscle Strength Muscle Weakness Physiopathology Muscle, Skeletal Weightlessness Simulation Analysis Of Variance Biomechanical Phenomena Electromyography Germany Linear Models Lower Extremity Etiology Prevention & Control Recovery Of Function Time Factors Vibration Therapeutic Use Weightlessness Countermeasures Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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