NDLI: Endurance exercise attenuates ventilator-induced diaphragm dysfunction

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Smuder, Ashley J. Min, Kisuk Hudson, Matthew B. Kavazis, Andreas N. Kwon, Oh-Sung Nelson, W. Bradley Powers, Scott K.
Description	Country affiliation: United States Author Affiliation: Smuder AJ ( Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA.)
Abstract	Controlled mechanical ventilation (MV) is a life-saving measure for patients in respiratory failure. However, MV renders the diaphragm inactive leading to diaphragm weakness due to both atrophy and contractile dysfunction. It is now established that oxidative stress is a requirement for MV-induced diaphragmatic proteolysis, atrophy, and contractile dysfunction to occur. Given that endurance exercise can elevate diaphragmatic antioxidant capacity and the levels of the cellular stress protein heat shock protein 72 (HSP72), we hypothesized that endurance exercise training before MV would protect the diaphragm against MV-induced oxidative stress, atrophy, and contractile dysfunction in female Sprague-Dawley rats. Our results confirm that endurance exercise training before MV increased both HSP72 and the antioxidant capacity in the diaphragm. Importantly, compared with sedentary animals, exercise training before MV protected the diaphragm against MV-induced oxidative damage, protease activation, myofiber atrophy, and contractile dysfunction. Further, exercise protected diaphragm mitochondria against MV-induced oxidative damage and uncoupling of oxidative phosphorylation. These results provide the first evidence that exercise can provide protection against MV-induced diaphragm weakness. These findings are important and establish the need for future experiments to determine the mechanism(s) responsible for exercise-induced diaphragm protection.
File Format	HTM / HTML
ISSN	87507587
e-ISSN	15221601
DOI	10.1152/japplphysiol.01086.2011
Journal	Journal of Applied Physiology
Issue Number	3
Volume Number	112
Language	English
Publisher	American Physiological Society
Publisher Date	2012-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Diaphragm Physiopathology Physical Conditioning, Animal Physiology Physical Endurance Respiration, Artificial Adverse Effects Animals Antioxidants Metabolism Body Weight Cell Respiration Hsp72 Heat-shock Proteins Mitochondria Muscle Contraction Muscle, Skeletal Muscular Atrophy Myofibrils Oxidative Phosphorylation Oxidative Stress Peptide Hydrolases Proteolysis Rna-binding Proteins Genetics Rats, Sprague-dawley Transcription Factors
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Sports Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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