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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Risse, Paul-André Lavoie-Lamoureux, Anouk Jo, Taisuke Tsuchiya, Kimitake Siddiqui, Sana Martin, James G. |
| Description | Country affiliation: Canada Author Affiliation: Risse PA ( Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada.) |
| Abstract | Innate airway hyperresponsiveness (AHR) is well modeled by two strains of rat, the hyperresponsive Fischer 344 rat and the normoresponsive Lewis rat. Arginase has been implicated in AHR associated with allergic asthma models. We addressed the role of arginase in innate AHR using the Fischer-Lewis model. In vivo arginase inhibition with N(ω)-hydroxy-nor-arginine (nor-NOHA) was evaluated on methacholine-induced bronchoconstriction in the Fischer and the Lewis rats. Arginase activity and mRNA expression were quantified in structural and resident cells of the proximal airway tree. The effect of nor-NOHA was evaluated on cultured tracheal smooth muscle proliferation. Fischer rats exhibited significantly greater changes in respiratory resistance and elastance in response to methacholine compared with Lewis rats. nor-NOHA reduced the methacholine-induced bronchoconstriction in the central airways of Lewis rats, while it did not change the innate AHR of Fischer rats. Lewis rats exhibited greater arginase activity in tracheal smooth muscle but a lower proliferation rate compared with Fischer rats. Smooth muscle proliferation was not affected by nor-NOHA in either strain of rats. The strain-specific arginase expression in the smooth muscle may contribute to the differences in sensitivity of the methacholine challenged airways of Lewis and Fischer rats to inhibition of arginase. |
| File Format | HTM / HTML |
| ISSN | 87507587 |
| e-ISSN | 15221601 |
| Journal | Journal of Applied Physiology |
| Issue Number | 6 |
| Volume Number | 116 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2014-03-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Arginase Antagonists & Inhibitors Arginine Analogs & Derivatives Bronchial Hyperreactivity Prevention & Control Bronchial Provocation Tests Bronchoconstriction Drug Effects Bronchoconstrictor Agents Enzyme Inhibitors Pharmacology Lung Methacholine Chloride Animals Genetics Metabolism Enzymology Physiopathology Cell Proliferation Cells, Cultured Dose-response Relationship, Drug Gene Expression Regulation, Enzymologic Myocytes, Smooth Muscle Pathology Rna, Messenger Rats, Inbred F344 Rats, Inbred Lew Species Specificity Comparative Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Sports Science |
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