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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chowdhuri, Susmita Pranathiageswaran, Sukanya Franco-Elizondo, Rene Jayakar, Arunima Hosni, Arwa Nair, Ajin Badr, M. Safwan |
| Description | Author Affiliation: Chowdhuri S ( Medical Service, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan); Pranathiageswaran S ( Division of Pulmonary/Critical Care and Sleep Medicine, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan.); Franco-Elizondo R ( Medical Service, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan); Jayakar A ( Medical Service, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan); Hosni A ( Medical Service, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan); Nair A ( Medical Service, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan); Badr MS ( Medical Service, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan) |
| Abstract | The reason for increased sleep-disordered breathing with a predominance of central apneas in the elderly is unknown. We speculate that ventilatory control instability may provide a link between aging and the onset of unstable breathing during sleep. We sought to investigate potential underlying mechanisms in healthy, elderly adults during sleep. We hypothesized that there is 1) a decline in respiratory plasticity or long-term facilitation (LTF) of ventilation and/or 2) increased ventilatory chemosensitivity in older adults during non-, this should be hyphenated, non-rapid rapid eye movement (NREM) sleep. Fourteen elderly adults underwent 15, 1-min episodes of isocapnic hypoxia (EH), nadir O2 saturation: 87.0 ± 0.8%. Measurements were obtained during control, hypoxia, and up to 20 min of recovery following the EH protocol, respectively, for minute ventilation (VI), timing, and inspiratory upper-airway resistances (RUA). The results showed the following. 1) Compared with baseline, there was a significant increase in VI (158 ± 11%, P < 0.05) during EH, but this was not accompanied by augmentation of VI during the successive hypoxia trials nor in VI during the recovery period (94.4 ± 3.5%, P = not significant), indicating an absence of LTF. There was no change in inspiratory RUA during the trials. This is in contrast to our previous findings of respiratory plasticity in young adults during sleep. Sham studies did not show a change in any of the measured parameters. 2) We observed increased chemosensitivity with increased isocapnic hypoxic ventilatory response and hyperoxic suppression of VI in older vs. young adults during NREM sleep. Thus increased chemosensitivity, unconstrained by respiratory plasticity, may explain increased periodic breathing and central apneas in elderly adults during NREM sleep. |
| File Format | HTM / HTML |
| ISSN | 87507587 |
| e-ISSN | 15221601 |
| Journal | Journal of Applied Physiology |
| Issue Number | 10 |
| Volume Number | 119 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2015-11-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Aging Physiology Chemoreceptor Cells Long-term Potentiation Pulmonary Ventilation Sleep Stages Polysomnography Respiratory Mechanics Research Support, U.s. Gov't, Non-p.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Sports Science |
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