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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ponting, J. M. Kumar, S. |
| Description | Country affiliation: United kingdom Author Affiliation: Ponting JM ( Department of Clinical Research, Christie Hospital, Manchester, UK.) |
| Abstract | Hyaluronectin is an extracellular matrix glycoprotein which specifically binds to hyaluronan. Isoforms of hyaluronectin are present in nervous and mesenchymal tissues but, while the nervous tissue isoform has been characterised in some detail, less is known about the mesenchymal isoform. Although its tissue localisation suggests a role in tumour development, neither its cellular origin nor its exact function are known. In this study we demonstrate hyaluronectin synthesis in fibroblasts and smooth muscle cells in vitro. The pattern of immunolocalisation of hyaluronectin in fibroblasts depended on the cell type, length of time spent by the cells in culture and cell density. Immunoreactivity in sparsely plated migratory cells was seen mainly in a patchy distribution at the attached cell surface and in the migration tracks left by the cells on the subtratum. In stationary cells a more uniform distribution associated with the attached cell surface was observed, while in confluent cultures hyaluronectin immunoreactivity was mainly seen as a network of fibrillar material above the cell. The pattern of staining was distinct from that of other hyaluronan-binding proteins. Immunoprecipitation, using antihyaluronectin antibodies, of the substratum-attached material deposited by human fetal fibroblasts revealed a family of proteins ranging from 22 to 90 kDa, the major protein being of approximately 60 kDa. These results lead us to propose that hyaluronectin plays an important role in cell migration, probably by regulation of hyaluronan distribution and binding. |
| File Format | HTM / HTML |
| ISSN | 14697580 |
| e-ISSN | 14697580 |
| Journal | Journal of Anatomy |
| Volume Number | 187 Pt 2 |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 1995-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Anatomy Antigens, Cd44 Extracellular Matrix Proteins Mesoderm Chemistry Muscle, Smooth Skin Animals Biosynthesis Cells, Cultured Chick Embryo Fibroblasts Metabolism Fibronectins Fluorescent Antibody Technique Talin Tumor Cells, Cultured Comparative Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anatomy Cell Biology Developmental Biology Histology Molecular Biology Ecology, Evolution, Behavior and Systematics |
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