NDLI: Activation of cortical and inhibited differentiation of medullary epithelial cells in the thymus of lymphotoxin-beta receptor-deficient mice: an ultrastructural study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Milicevic, N. M. Nohroudi, K. Milicevic, Zì Westermann, J.
Description	Author Affiliation: Milicevic NM ( Institute of Histology and Embryology, Faculty of Medicine, University of Beograd, Serbia. emilicen@etf.bg.ac.yu)
Abstract	The reciprocal influences of thymic lymphocyte and nonlymphocyte populations, i.e. thymic cross-talk, are necessary for the proper maturation of thymocytes and the development/maintenance of thymic stromal microenvironments. Although the molecular influences exerted by thymic stromal cells on maturing thymocytes have been extensively studied, the identity of signalling molecules used by thymocytes to influence the thymic stromal cells is still largely unknown. Our study provides the first ultrastructural evidence that the functional lymphotoxin-beta receptor (LTbetaR) signalling pathway is engaged in the cross-talk between thymocytes and the thymic stromal cell population. We show that LTbetaR signalling is of the utmost significance for the preservation of the subcellular integrity of all thymic epithelial cells. In the absence of LTbetaR there is (1) hypertrophy and activation of cortical thymic epithelial cells, (2) the complete loss of fully differentiated medullary thymic epithelial cells, and (3) the inhibited differentiation of remaining medullary thymic epithelial cells with the appearance of prominent intercellular cysts in the thymic medulla.
File Format	HTM / HTML
ISSN	14697580
e-ISSN	14697580
DOI	10.1111/j.1469-7580.2007.00851.x
Journal	Journal of Anatomy
Issue Number	2
Volume Number	212
Language	English
Publisher	Wiley
Publisher Date	2008-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Anatomy Epithelial Cells Lymphotoxin Beta Receptor Deficiency Microscopy, Electron Thymus Gland Ultrastructure Animals Mice Mice, Inbred C57bl Ultrasonography Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Anatomy Cell Biology Developmental Biology Histology Molecular Biology Ecology, Evolution, Behavior and Systematics

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Activation of cortical and inhibited differentiation of medullary epithelial cells in the thymus of lymphotoxin-beta receptor-deficient mice: an ultrastructural study.