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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schulten, Véronique Radakovics, Astrid Hartz, Christina Mari, Adriano Vazquez-Cortes, Sonia Fernandez-Rivas, Montserrat Lauer, Iris Jahn-Schmid, Beatrice Eiwegger, Thomas Scheurer, Stephan Bohle, Barbara |
| Description | Country affiliation: Austria Author Affiliation: Schulten V ( Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria.) |
| Abstract | BACKGROUND: Pru p 3, the nonspecific lipid transfer protein from peach, is an important plant food allergen that frequently induces systemic reactions. OBJECTIVE: We sought to analyze the allergic T-cell response to Pru p 3. METHODS: PBMCs from Italian and Spanish patients with peach allergy were stimulated with purified natural Pru p 3. Allergen-specific T-cell lines were used to identify T-cell epitopes of Pru p 3. Pru p 3-specific T-cell clones (TCCs) were analyzed for allergen-induced secretion of IL-4, IFN-gamma, and IL-10 and expression of the integrin beta7, a receptor critical for gut homing. RESULTS: No difference in T-cell responses of Italian and Spanish patients was found. Among several T cell-activating regions, Pru p 3(13-27), Pru p 3(34-48), Pru p 3(43-57), and Pru p 3(61-75) were most frequently recognized in 18 Pru p 3-specific T-cell lines. The majority of 32 Pru p 3-specific TCCs belonged to the T(H)2 subset. In contrast to TCCs specific for other plant food and pollen allergens, only a limited number of Pru p 3-specific TCCs produced significant amounts of IL-10. The expression of integrin beta7 on Pru p 3-specific TCCs was comparable with that observed on peanut-specific TCCs and higher compared with that seen in different pollen-specific TCCs. CONCLUSION: The T-cell response to Pru p 3 is dominated by T(H)2 cells presumably primed in the gut. The identification of relevant T cell-activating regions provides a basis for engineering hypoallergenic variants of Pru p 3 with less IgE binding and retained T-cell stimulatory capacity for safe immunotherapy of peach allergy. |
| File Format | HTM / HTML |
| ISSN | 00916749 |
| e-ISSN | 10976825 |
| Journal | Journal of Allergy and Clinical Immunology |
| Issue Number | 1 |
| Volume Number | 124 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Immunology Allergens Classification Antigens, Plant Carrier Proteins Prunus Immunology T-lymphocytes Adolescent Amino Acid Sequence Epitopes, T-lymphocyte Flow Cytometry Integrin Beta Chains Metabolism Interleukin-10 Lymphocyte Activation Molecular Sequence Data Phenotype Plant Proteins Th2 Cells Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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