NDLI: Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes.

Please wait, while we are loading the content...

Year: 2017 Volume: 139

Year: 2016 Volume: 138

Year: 2016 Volume: 137

Year: 2015 Volume: 136

Year: 2015 Volume: 135

Year: 2014 Volume: 134

Year: 2014 Volume: 133

Year: 2013 Volume: 132

Year: 2013 Volume: 131

Year: 2012 Volume: 130

Year: 2012 Volume: 129

Year: 2011 Volume: 128

Year: 2011 Volume: 127

Year: 2010 Volume: 126

Year: 2010 Volume: 125

Year: 2009 Volume: 124

Year: 2009 Volume: 124 Issue: 6

Year: 2009 Volume: 124 Issue: 6 Supplementary

Year: 2009 Volume: 124 Issue: 5

Year: 2009 Volume: 124 Issue: 4

Year: 2009 Volume: 124 Issue: 3

Development of a routine newborn screening protocol for severe combined immunodeficiency.

Leukotriene E4: perspective on the forgotten mediator.

Neonatal innate cytokine responses to BCG controlling T-cell development vary between populations.

Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes.

Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish Network on Mastocytosis in a series of 145 patients.

Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-kappaB pathways in rhinovirus-infected epithelial cells.

Lung mast cells are a source of secreted phospholipases A2.

Fibronectin is a TH1-specific molecule in human subjects.

Polymeric immunoglobulin receptor may link asthma with increased risk of pneumococcal disease.

TH2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells.

Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese.

Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma.

Role of omalizumab and steroids in Churg-Strauss syndrome.

Inadequate health literacy is associated with increased asthma morbidity in a population sample.

Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research Centers.

The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications.

Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005-2006.

Early onset of action of a 5-grass-pollen 300-IR sublingual immunotherapy tablet evaluated in an allergen challenge chamber.

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry.

Unmet needs in severe chronic upper airway disease (SCUAD).

Rotavirus vaccine induced diarrhea in a child with severe combined immune deficiency.

Genetics and pharmacogenetics of the leukotriene pathway.

An IgE-associated polymorphism in STAT6 alters NF-kappaB binding, STAT6 promoter activity, and mRNA expression.

Open-label maintenance after milk oral immunotherapy for IgE-mediated cow's milk allergy.

Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.

Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma.

Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.

Comèl-Netherton syndrome defined as primary immunodeficiency.

The placebo effect in asthma: Far more complex than simply 'I shall please'.

Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma.

Elucidation of asthma phenotypes in atopic teenagers through parallel immunophenotypic and clinical profiling.

Our evolving understanding of the functional role of filaggrin in atopic dermatitis.

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.

Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum.

Association of the cysteinyl leukotriene receptor 1 gene with atopy in the British 1958 birth cohort.

Self-reported allergic reactions to peanut and tree nuts occurring on commercial airlines.

Mammalian meat-induced anaphylaxis: clinical relevance of anti-galactose-alpha-1,3-galactose IgE confirmed by means of skin tests to cetuximab.

Consistency of sputum eosinophilia in difficult-to-treat asthma: a 5-year follow-up study.

Pulmonary nontuberculous mycobacterial infections in hyper-IgE syndrome.

Allergic or nonallergic rhinitis?

Year: 2009 Volume: 124 Issue: 3 Supplementary

Year: 2009 Volume: 124 Issue: 3 Supplementary 2

Year: 2009 Volume: 124 Issue: 2

Year: 2009 Volume: 124 Issue: 2 Supplementary

Year: 2009 Volume: 124 Issue: 1

Year: 2009 Volume: 123

Year: 2008 Volume: 122

Year: 2008 Volume: 121

Year: 2007 Volume: 120

Year: 2007 Volume: 119

Year: 2006 Volume: 118

Year: 2006 Volume: 117

Year: 2005 Volume: 116

Year: 2005 Volume: 115

Year: 2004 Volume: 113

Year: 2001 Volume: 108

Year: 2000 Volume: 106

Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kanda, Akira Driss, Virginie Hornez, Nicolas Abdallah, Marwan Roumier, Thomas Abboud, Georges Legrand, Fanny Staumont-Sallé, Delphine Quéant, Severine Bertout, Julie Fleury, Sébastien Rémy, Patrick Papin, Jean-Paul Julia, Valérie Capron, Monique Dombrowicz, David
Description	Country affiliation: France Author Affiliation: Kanda A ( Inserm U547, Lille, France)
Abstract	BACKGROUND: Eosinophils are key players in T(H)2-driven pathologies, such as allergic lung inflammation. After IL-5- and eotaxin-mediated tissue recruitment, they release several cytotoxic and inflammatory mediators. However, their exact contribution to asthma remains controversial. Indeed, in human subjects anti-IL-5 treatment inhibits eosinophilia but not antigen-induced airway hyperresponsiveness (AHR). Likewise, lung fibrosis is abrogated in 2 strains of eosinophil-deficient mice, whereas AHR is inhibited in only one of them. Finally, eosinophils have been shown to attract T(H)2 lymphocytes at the inflammatory site. OBJECTIVE: The ability of eosinophils to promote AHR and lung inflammation independently of lymphocytes was investigated. METHODS: Adoptive transfers of resting or activated eosinophils from IL-5 transgenic mice were performed into naive BALB/c mice, mice with severe combined immunodeficiency, and IFN-gamma-deficient BALB/c recipients. RESULTS: Adoptively transferred eosinophils induced lung inflammation, fibrosis, collagen deposition, and AHR not only in BALB/c mice but also in recipient mice with severe combined immunodeficiency. Surprisingly, IFN-gamma expression was increased in lungs from eosinophil-transferred animals. Furthermore, IFN-gamma neutralization in recipients partially inhibited eosinophil-induced AHR. Moreover, IFN-gamma-deficient eosinophils or eosinophils treated with a blocking anti-IFN-gamma receptor antibody failed to induce AHR in IFN-gamma-deficient recipients. Finally, in vitro and at low concentrations, IFN-gamma increased eosinophil peroxidase release, potentiated chemotaxis, and prolonged survival, suggesting the existence of an autocrine mechanism. CONCLUSIONS: These results support the important and previously unsuspected contribution of eosinophils to lung inflammation independently of lymphocytes through production of IFN-gamma, the prototypical T(H)1 cytokine.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
Journal	Journal of Allergy and Clinical Immunology
Issue Number	3
Volume Number	124
Language	English
Publisher	Elsevier
Publisher Date	2009-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Bronchial Hyperreactivity Immunology Eosinophils Interferon-gamma Metabolism Interleukin-5 Lymphocytes Pneumonia Adoptive Transfer Animals Etiology Chemotaxis Eosinophil Peroxidase Genetics Lung Pathology Mice Mice, Inbred Balb C Mice, Knockout Mice, Scid Mice, Transgenic Receptors, Interferon Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in