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Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McDonald, Douglas R. Goldman, Frederick Gomez-Duarte, Oscar D. Issekutz, Andrew C. Kumararatne, Dinakantha S. Doffinger, Rainer Geha, Raif S.
Description	Country affiliation: United States Author Affiliation: McDonald DR ( Division of Immunology, Children's Hospital, Boston, and the Department of Pediatrics, Harvard Medical School, Boston, Mass, USA.)
Abstract	BACKGROUND: IL-1 receptor-associated kinase 4 (IRAK-4) is an effector of the Toll-like receptor and IL-1 receptor pathways that plays a critical role in innate immune responses. The role of IRAK-4 in adaptive immune functions in human subjects is incompletely understood. OBJECTIVE: We sought to evaluate T-cell function in IRAK-4 deficient patients. METHODS: We compared upregulation of CD25 and CD69 on T cells and production of IL-2, IL-6, and IFN-gamma after stimulation of PBMCs from 4 IRAK-4-deficient patients and healthy control subjects with anti-CD3 and anti-CD28. RESULTS: Upregulation of CD25 and CD69 on T cells and production of IL-6 and IFN-gamma, but not IL-2, was significantly reduced in IRAK-4-deficient patients. CONCLUSIONS: IRAK-4-deficient patients have defects in T-cell activation.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
DOI	10.1016/j.jaci.2010.05.013
Journal	Journal of Allergy and Clinical Immunology
Issue Number	2
Volume Number	126
Language	English
Publisher	Elsevier
Publisher Date	2010-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Genetic Diseases, Inborn Immunologic Deficiency Syndromes Interleukin-1 Receptor-associated Kinases Lymphocyte Activation Receptors, Antigen, T-cell Immunology T-lymphocytes Adaptive Immunity Genetics Antigens, Cd Biosynthesis Antigens, Differentiation, T-lymphocyte Case-control Studies Cytokines Enzymology Metabolism Interleukin-2 Receptor Alpha Subunit Lectins, C-type Up-regulation Comparative Study Multicenter Study Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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