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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Moreira, Ana Paula Cavassani, Karen A. Hullinger, Rikki Rosada, Rogério S. Fong, Daniel J. Murray, Lynne Hesson, Dave P. Hogaboam, Cory M. |
| Description | Country affiliation: United States Author Affiliation: Moreira AP ( Immunology Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-2200, USA. anapaula@umich.edu) |
| Abstract | BACKGROUND: Aspergillus fumigatus conidia aggravate asthmatic responses. Lung macrophages normally kill fungal conidia, but the presence of type 2 cytokines during asthma contributes to the alternative (or M2) activation of these cells, which secrete proallergic factors and exhibit impaired innate immunity. OBJECTIVE: Considering that pentraxins modulate macrophage function, we examined the effect of C-reactive protein (CRP) and serum amyloid P (SAP) in an experimental model of A fumigatus-induced allergic airway disease. METHODS: The effects of SAP and CRP on M2 macrophage differentiation were examined in vitro, and the in vivo effects of these pentraxins were analyzed in the asthma model. RESULTS: SAP inhibited the generation of M2 markers, such as arginase and the chitinase Ym-1, through an FcγR-dependent mechanism in cultured macrophages. This effect correlated with a decrease in signal transducer and activator of transcription 6 (STAT6) phosphorylation in SAP-treated M2 macrophages. In vivo treatment with SAP significantly decreased methacholine-induced bronchial resistance, mucus cell metaplasia, the number of 'found in inflammatory zone 1' (FIZZ1)-positive cells in the lungs, and collagen deposition compared with the control group. CRP had a modest effect on M2 differentiation, and in vivo treatment with CRP had a minor effect or exacerbated A fumigatus-induced lung disease. Finally, the adoptive transfer of SAP-pretreated M2 macrophages into allergic mice significantly attenuated disease when compared with nontransferred or M2-transferred control groups. CONCLUSIONS: These findings demonstrate that SAP is a potent inhibitor of M2 macrophage differentiation and represents a novel therapy in A fumigatus-induced allergic disease. |
| File Format | HTM / HTML |
| ISSN | 00916749 |
| e-ISSN | 10976825 |
| Journal | Journal of Allergy and Clinical Immunology |
| Issue Number | 4 |
| Volume Number | 126 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Immunology Aspergillosis, Allergic Bronchopulmonary Prevention & Control Aspergillus Fumigatus Immunology Asthma Macrophage Activation Drug Effects Serum Amyloid P-component Pharmacology Spores, Fungal Airway Remodeling Animals Microbiology Physiology C-reactive Protein Cell Differentiation Disease Models, Animal Macrophages Cytology Macrophages, Alveolar Mice Mice, Inbred C57bl Administration & Dosage |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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