NDLI: Population-based study of multiplexed IgE sensitization in relation to asthma, exhaled nitric oxide, and bronchial responsiveness.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Patelis, Antonios Gunnbjörnsdottir, Maria Malinovschi, Andrei Matsson, Per Onell, Annica Högman, Marieann Alving, Kjell Janson, Christer
Spatial Coverage	Sweden
Description	Country affiliation: Sweden Author Affiliation: Patelis A ( Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden. antonios.patelis@medsci.uu.se)
Abstract	BACKGROUND: IgE sensitization is an important risk factor for the development of asthma. OBJECTIVE: The aim of this study was to investigate the IgE antibody profile for a broad spectrum of allergen molecules in asthmatic patients. METHODS: Participants from the European Community Respiratory Health Survey II (n=467) were tested with ImmunoCAP ISAC against 103 allergen molecules. The presence of bronchial hyperresponsiveness was measured with a methacholine challenge test and bronchial inflammation with fraction of exhaled nitric oxide (Feno). RESULTS: A total of 38% of the controls and 72% of the asthmatic patients were sensitized against at least 1 of the allergen components (P<.0001). Asthma was independently related to having IgE antibodies against pollen (odds ratio=2.2) and perennial airway allergens (odds ratio=5.6), increased Feno was independently related to having IgE antibodies against food allergens and perennial allergens, while bronchial responsiveness was independently associated with having IgE antibodies against only perennial allergens. Sensitization to food allergens was related to asthma and increased Feno if IgE antibody against pollen allergens was present. Simultaneous sensitization to perennial, pollen, and food allergens involves the highest risk of asthma (odds ratio=18.3), bronchial inflammation, and responsiveness. CONCLUSIONS: Feno, bronchial responsiveness, and the risk of asthma increase with multiple sensitizations to different allergen groups. We show for the first time that the presence of IgE antibodies against food allergens is independently associated with increased Feno and increases the risk of asthma in subjects with simultaneous sensitization to pollen allergens.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
Journal	Journal of Allergy and Clinical Immunology
Issue Number	2
Volume Number	130
Language	English
Publisher	Elsevier
Publisher Date	2012-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Asthma Immunology Bronchial Hyperreactivity Food Hypersensitivity Hypersensitivity, Immediate Immunoglobulin E Allergens Epidemiology Physiopathology Biological Markers Metabolism Bronchial Provocation Tests Exhalation Health Surveys Blood Methacholine Chloride Nitric Oxide Pollen Respiratory Function Tests Risk Factors Sweden Multicenter Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide.

Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: a random-sample population study.

The value of exhaled nitric oxide in predicting bronchial hyperresponsiveness in children.

The fractional exhaled nitric oxide and serum high sensitivity C-reactive protein levels in cough variant asthma and typical bronchial asthma.

Airway responsiveness and inflammation in adolescent elite swimmers.

Atopic sensitization to common allergens without symptoms or signs of airway disorders does not increase exhaled nitric oxide.

Farming environments and childhood atopy, wheeze, lung function, and exhaled nitric oxide.

Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthma.

Occupational asthma caused by IgE-mediated sensitization to multiple woods.

Population-based study of multiplexed IgE sensitization in relation to asthma, exhaled nitric oxide, and bronchial responsiveness.

Similar Documents

Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide.

Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: a random-sample population study.

The value of exhaled nitric oxide in predicting bronchial hyperresponsiveness in children.

The fractional exhaled nitric oxide and serum high sensitivity C-reactive protein levels in cough variant asthma and typical bronchial asthma.

Airway responsiveness and inflammation in adolescent elite swimmers.

Atopic sensitization to common allergens without symptoms or signs of airway disorders does not increase exhaled nitric oxide.

Farming environments and childhood atopy, wheeze, lung function, and exhaled nitric oxide.

Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthma.

Occupational asthma caused by IgE-mediated sensitization to multiple woods.

Population-based study of multiplexed IgE sensitization in relation to asthma, exhaled nitric oxide, and bronchial responsiveness.