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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Davies, Janet M. Platts-Mills, Thomas A. Aalberse, Rob C. |
| Description | Country affiliation: Australia Author Affiliation: Davies JM ( Lung and Allergy Research Centre, School of Medicine, University of Queensland, and the Translational Research Institute, Woolloongabba, Australia.) |
| Abstract | Our understanding of the origin and fate of the IgE-switched B cell has been markedly improved by studies in mouse models. The immediate precursor of the IgE-switched B cell is either a relatively naive nonswitched B cell or a mature IgG-switched B cell. These 2 routes are referred to as the direct and indirect pathways, respectively. IgE responses derived from each pathway differ significantly, largely reflecting the difference in time spent in a germinal center and thus time for clonal expansion, somatic hypermutation, affinity maturation, and acquisition of a memory phenotype. The clinical and therapeutic implications for IgE responses in human subjects are still a matter of debate, largely because the immunization procedures used in the animal models are significantly different from classical atopic sensitization to allergens from pollen and mites. On the basis of the limited information available, it seems likely that these atopic IgE responses are characterized by a relatively low IgG/IgE ratio, low B-cell memory, and modest affinity maturation, which fits well with the direct switching pathway. It is still unresolved how the IgE response evolves to cover a wide epitope repertoire involving many epitopes per allergen, as well as many different allergens from a single allergen source. |
| File Format | HTM / HTML |
| ISSN | 00916749 |
| e-ISSN | 10976825 |
| Journal | Journal of Allergy and Clinical Immunology |
| Issue Number | 4 |
| Volume Number | 131 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Immunology B-lymphocytes Immunology Hypersensitivity, Immediate Immunoglobulin E Immunoglobulin G Immunologic Memory Allergens Animals Pathology Cell Differentiation Cell Proliferation Epitopes Germinal Center Immunoglobulin Class Switching Mice Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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