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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hafkamp-de Groen, Esther Lingsma, Hester F. Caudri, Daan Levie, Deborah Wijga, Alet Koppelman, Gerard H. Duijts, Liesbeth Jaddoe, Vincent W. V. Smit, Henriëtte A. Kerkhof, Marjan Moll, Henriëtte A. Hofman, Albert Steyerberg, Ewout W. de Jongste, Johan C. Raat, Hein |
| Description | Author Affiliation: Hafkamp-de Groen E ( Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands) |
| Abstract | BACKGROUND: The Prevention and Incidence of Asthma and Mite Allergy (PIAMA) risk score predicts the probability of having asthma at school age among preschool children with suggestive symptoms. OBJECTIVE: We sought to externally validate the PIAMA risk score at different ages and in ethnic and socioeconomic subgroups of children in addition to updating it. METHODS: We studied 2877 children with preschool asthma-like symptoms participating in the multiethnic, prospective, population-based cohort study Generation R. The PIAMA risk score was assessed at preschool age, and asthma was predicted at age 6 years. Discrimination (concordance index [C-index]) and calibration were calculated. The PIAMA risk score was updated, and its performance was similarly analyzed. RESULTS: At age 6 years, 6% (168/2877) of the children had asthma. The discriminative ability of the original PIAMA risk score to predict asthma in Generation R was similar compared with that in the PIAMA cohort (C-index = 0.74 vs 0.71). The predicted risks by using the original PIAMA risk score for having asthma at the age of 6 years tended to be slightly higher than the observed risks (8% vs 6%). No differences in discriminative ability were found at different ages or in ethnic and socioeconomic subgroups (P > .05). The updated PIAMA risk score had a C-index of 0.75. CONCLUSIONS: The PIAMA risk score showed good external validity. The discriminative ability was similar at different ages and in ethnic and socioeconomic subgroups of preschool children, which suggests good generalizability. Further studies are needed to reproduce the predictive performance of the updated PIAMA risk score in other populations and settings and to assess its clinical relevance. |
| File Format | HTM / HTML |
| ISSN | 00916749 |
| e-ISSN | 10976825 |
| Journal | Journal of Allergy and Clinical Immunology |
| Issue Number | 6 |
| Volume Number | 132 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Immunology Asthma Diagnosis Epidemiology Ethnic Groups Socioeconomic Factors Child, Preschool Infant Predictive Value Of Tests Prognosis Prospective Studies Risk Factors Questionnaires Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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