NDLI: Large maculopapular cutaneous lesions are associated with favorable outcome in childhood-onset mastocytosis.

Please wait, while we are loading the content...

Year: 2017 Volume: 139

Year: 2016 Volume: 138

Year: 2016 Volume: 137

Year: 2015 Volume: 136

Year: 2015 Volume: 136 Issue: 6

Evolution pathways of IgE responses to grass and mite allergens throughout childhood.

Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent.

Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels.

IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation.

Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis.

Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis.

Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood.

CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies.

Usefulness of recombinant Î³-gliadin 1 for identifying patients with celiac disease and monitoring adherence to a gluten-free diet.

Preventive effect of nasal filters on allergic rhinitis: A randomized, double-blind, placebo-controlled crossover park study.

Increased expression of the epithelial anion transporter pendrin/SLC26A4 in nasal polyps of patients with chronic rhinosinusitis.

The diversity of Bet v 1-specific IgG4 antibodies remains mostly constant during the course of birch pollen immunotherapy.

Large maculopapular cutaneous lesions are associated with favorable outcome in childhood-onset mastocytosis.

Efficacy of baked milk oral immunotherapy in baked milk-reactive allergic patients.

An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation.

Use of asthma medication during pregnancy and risk of specific congenital anomalies: A European case-malformed control study.

Allergic sensitization is age-dependently associated with rhinitis, but less so with asthma.

Host, disease, and antiretroviral factors are associated with normalization of the CD4:CD8 ratio after initiating antiretroviral therapy.

Immunoglobulin deficiency in patients with chronic rhinosinusitis: Systematic review of the literature and meta-analysis.

Mite allergen-specific IgE is detectable in bronchial secretions of patients with nonatopic asthma and correlates with mucosal expression of periostin.

Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum.

Furry pets modulate gut microbiota composition in infants at risk for allergic disease.

Allergy immunotherapy for allergic rhinitis effectively prevents asthma: Results from a large retrospective cohort study.

Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization.

Neuropeptide signaling through neurokinin-1 and neurokinin-2 receptors augments antigen presentation by human dendritic cells.

Olfaction in allergic rhinitis: A systematic review.

Claudin 5 in a murine model of allergic asthma: Its implication and response to steroid treatment.

Immunoactive prebiotics transiently prevent occurrence of early atopic dermatitis among low-atopy-risk infants.

Acute and chronic systemic corticosteroid-related complications in patients with severe asthma.

Critical link between glycogen synthase kinase 3ß and forkhead box P3 in patients with chronic rhinosinusitis with nasal polyps.

Reply: To PMID 25748064.

Leprosy is teaching us the immunopathogenesis of inflammatory skin disease.

Direct costs of adult chronic rhinosinusitis by using 4 methods of estimation: Results of the US Medical Expenditure Panel Survey.

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations.

Reply: To PMID 25747720.

The common food additive carrageenan and the alpha-gal epitope.

Association of periostin expression with eosinophilic inflammation in nasal polyps.

Defective nuclear entry of hydrolases prevents neutrophil extracellular trap formation in patients with chronic granulomatous disease.

Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis.

Chronic rhinosinusitis pathogenesis.

Drivers of chronic rhinosinusitis: Inflammation versus infection.

The Journal of Allergy and Clinical Immunology: A 17-year perspective.

Timing is everything: Targeting IgE to reduce asthma exacerbation risk.

Patient-reported outcome measures for adult chronic rhinosinusitis: A systematic review and quality assessment.

Factors influencing growth effects of inhaled corticosteroids in children.

Year: 2015 Volume: 136 Issue: 5

Year: 2015 Volume: 136 Issue: 4

Year: 2015 Volume: 136 Issue: 3

Year: 2015 Volume: 136 Issue: 2

Year: 2015 Volume: 136 Issue: 1

Year: 2015 Volume: 135

Year: 2014 Volume: 134

Year: 2014 Volume: 133

Year: 2013 Volume: 132

Year: 2013 Volume: 131

Year: 2012 Volume: 130

Year: 2012 Volume: 129

Year: 2011 Volume: 128

Year: 2011 Volume: 127

Year: 2010 Volume: 126

Year: 2010 Volume: 125

Year: 2009 Volume: 124

Year: 2009 Volume: 123

Year: 2008 Volume: 122

Year: 2008 Volume: 121

Year: 2007 Volume: 120

Year: 2007 Volume: 119

Year: 2006 Volume: 118

Year: 2006 Volume: 117

Year: 2005 Volume: 116

Year: 2005 Volume: 115

Year: 2004 Volume: 113

Year: 2001 Volume: 108

Year: 2000 Volume: 106

Large maculopapular cutaneous lesions are associated with favorable outcome in childhood-onset mastocytosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wiechers, Tim Rabenhorst, Anja Schick, Tina Preussner, Liane M. Förster, Anja Valent, Peter Horny, Hans-Peter Sotlar, Karl Hartmann, Karin
Description	Country affiliation: Germany Author Affiliation: Wiechers T ( Department of Dermatology, University of Cologne, Cologne, Germany.); Rabenhorst A ( Department of Dermatology, University of Cologne, Cologne, Germany.); Schick T ( Department of Dermatology, University of Cologne, Cologne, Germany); Preussner LM ( Department of Dermatology, University of Cologne, Cologne, Germany.); Förster A ( Department of Dermatology, University of Cologne, Cologne, Germany.); Valent P ( Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria.); Horny HP ( Institute of Pathology, Ludwig-Maximilians-Universität, Munich, Germany.); Sotlar K ( Institute of Pathology, Ludwig-Maximilians-Universität, Munich, Germany.); Hartmann K ( Department of Dermatology, University of Cologne, Cologne, Germany)
Abstract	BACKGROUND: Mastocytosis, characterized by pathologic accumulation of mast cells, can manifest itself in adulthood or childhood. Pediatric patients usually have cutaneous mastocytosis (CM) with mast cell infiltrates limited to the skin and spontaneous improvement of skin lesions after several years. However, there are some patients with persistent disease resembling adulthood-onset mastocytosis. OBJECTIVE: The current classification of CM differentiates between 3 subforms. In clinical practice we noticed that different variants of these subforms might exist, particularly in patients with childhood-onset mastocytosis. Therefore, in the present study, we aimed to investigate whether specific cutaneous lesions in patients with childhood-onset mastocytosis are associated with other disease parameters. METHODS: We analyzed 144 patients with a disease onset of less than age 17 years using a systematic dermatologic approach. RESULTS: One hundred twenty-two patients presented with maculopapular cutaneous mastocytosis (MPCM), 12 patients presented with diffuse CM, and 10 patients presented with solitary mastocytoma of the skin. Patients with MPCM showed particularly heterogeneous cutaneous lesions and were therefore grouped into 3 variants presenting either with small lesions (MPCM-small, skin lesions <1 cm in diameter; n = 19), large lesions (MPCM-large, skin lesions ≥ 1 cm in diameter; n = 89), or atypical lesions (MPCM-other, n = 14). Patients with MPCM-large lesions, compared with those with MPCM-small lesions, were characterized by significantly lower tryptase levels, shorter disease duration, and earlier disease onset. In addition, more patients with MPCM-large lesions exhibited spontaneous regression of cutaneous lesions. CONCLUSION: Our data show that patients with MPCM-large lesions compared with those with MPCM-small lesions have a more favorable disease course and suggest exploring the size of cutaneous lesions as a prognostic parameter in childhood-onset MPCM.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
Journal	Journal of Allergy and Clinical Immunology
Issue Number	6
Volume Number	136
Language	English
Publisher	Elsevier
Publisher Date	2015-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Urticaria Pigmentosa Diagnosis Adolescent Child, Preschool Infant Infant, Newborn Prognosis Proto-oncogene Proteins C-kit Genetics Tryptases Blood Pathology Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in