NDLI: Initial efficacy results of RTOG 0319: three-dimensional conformal radiation therapy (3D-CRT) confined to the region of the lumpectomy cavity for stage I/ II breast carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vicini, Frank Winter, Kathryn Wong, John Pass, Helen Rabinovitch, Rachel Chafe, Susan Arthur, Douglas Petersen, Ivy White, Julia McCormick, Beryl
Description	Country affiliation: United States Author Affiliation: Vicini F ( Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA. fvicini@beaumont.edu)
Abstract	PURPOSE: This prospective study (Radiation Therapy Oncology Group 0319) examines the use of three-dimensional conformal external beam radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI). Initial data on efficacy and toxicity are presented. METHODS AND MATERIALS: Patients with Stage I or II breast cancer with lesions < or =3 cm, negative margins and with < or =3 positive nodes were eligible. The 3D-CRT was 38.5 Gy in 3.85 Gy/fraction delivered 2x/day. Ipsilateral breast, ipsilateral nodal, contralateral breast, and distant failure (IBF, INF, CBF, DF) were estimated using the cumulative incidence method. Mastectomy-free, disease-free, and overall survival (MFS, DFS, OS) were recorded. The National Cancer Institute Common Terminology Criteria for Adverse Events, version 3, was used to grade acute and late toxicity. RESULTS: Fifty-eight patients were entered and 52 patients are eligible and evaluable for efficacy. The median age of patients was 61 years with the following characteristics: 46% tumor size <1 cm; 87% invasive ductal histology; 94% American Joint Committee on Cancer Stage I; 65% postmenopausal; 83% no chemotherapy; and 71% with no hormone therapy. Median follow-up is 4.5 years (1.7-4.8). Four-year estimates (95% CI) of efficacy are: IBF 6% (0-12%) [4% within field (0-9%)]; INF 2% (0-6%); CBF 0%; DF 8% (0-15%); MFS 90% (78-96%); DFS 84% (71-92%); and OS 96% (85-99%). Only two (4%) Grade 3 toxicities were observed. CONCLUSIONS: Initial efficacy and toxicity using 3D-CRT to deliver APBI appears comparable to other experiences with similar follow-up. However, additional patients, further follow-up, and mature Phase III data are needed to evaluate the extent of application, limitations, and value of this particular form of APBI.
File Format	HTM / HTML
ISSN	03603016
e-ISSN	1879355X
DOI	10.1016/j.ijrobp.2009.06.067
Journal	International Journal of Radiation OncologyastBiologyastPhysics
Issue Number	4
Volume Number	77
Language	English
Publisher	Elsevier
Publisher Date	2010-07-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Radiology Breast Neoplasms Radiotherapy Radiotherapy, Conformal Mortality Pathology Surgery Carcinoma, Ductal, Breast Mastectomy, Segmental Prospective Studies Adverse Effects Reproducibility Of Results Survival Analysis Tumor Burden Clinical Trial, Phase Ii Multicenter Study Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Cancer Research Radiation Oncology

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INITIAL EFFICACY RESULTS OF RTOG 0319: THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY (3D-CRT) CONFINED TO THE REGION OF THE LUMPECTOMY CAVITY FOR STAGE I/ II BREAST CARCINOMA

Late toxicity and patient self-assessment of breast appearance/satisfaction on RTOG 0319: a phase 2 trial of 3-dimensional conformal radiation therapy-accelerated partial breast irradiation following lumpectomy for stages I and II breast cancer.

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Four-year efficacy, cosmesis, and toxicity using three-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation.

Initial efficacy results of RTOG 0319: three-dimensional conformal radiation therapy (3D-CRT) confined to the region of the lumpectomy cavity for stage I/ II breast carcinoma.

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INITIAL EFFICACY RESULTS OF RTOG 0319: THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY (3D-CRT) CONFINED TO THE REGION OF THE LUMPECTOMY CAVITY FOR STAGE I/ II BREAST CARCINOMA

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