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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Meng, Xiangtao Xing, Ronge Liu, Song Yu, Huahua Li, Kecheng Qin, Yukun Li, Pengcheng |
| Description | Country affiliation: China Author Affiliation: Meng X ( Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.) |
| Abstract | Aminoethyl modified chitosan derivatives (AEMCSs) with different molecular weight (Mw) were synthesized by grafting aminoethyl group on different molecular weight chitosans and chitooligosaccharide. FTIR, (1)H NMR, (13)C NMR, elemental analysis and potentiometric titration results showed that branched polyethylimine chitosan was synthesized. Clinical Laboratory Standard Institute (CLSI) protocols were used to determine MIC for Gram-negative strain of Escherichia coli under different pH. The antibacterial activity of the derivatives was significantly improved compared with original chitosans, with MIC values against E. coli varying from 4 to 64 µg/mL depending on different Mw and pH. High molecular weight seems to be in favor of stronger antibacterial activity. At pH 7.4, derivatives with Mw above 27 kDa exhibited equivalent antibacterial activity (16 µg/mL), while oligosaccharide chitosan derivative with lower Mw (~1.4 kDa) showed decreased MIC of 64 µg/mL. The effect of pH on antibacterial activity is more complicated. An optimal pH for HAEMCS was found around 6.5 to give MIC as low as 4 µg/mL, while higher or lower pH compromised the activity. Cell integrity assay and SEM images showed evident cell disruption, indicating membrane disruption may be one possible mechanism for antibacterial activity. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Issue Number | 4 |
| Volume Number | 50 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Anti-bacterial Agents Chemistry Pharmacology Chitosan Cell Membrane Drug Effects Analogs & Derivatives Escherichia Coli Cytology Hydrogen-ion Concentration Microbial Sensitivity Tests Molecular Weight Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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