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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Venkatesan, Jayachandran Pallela, Ramjee Bhatnagar, Ira Kim, Se-Kwon |
| Description | Author Affiliation: Venkatesan J ( Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea. venkatjchem@gmail.com) |
| Abstract | Over the past few decades, artificial graft materials for bone tissue engineering are gaining much importance. In this study, tri-component scaffolds of chitosan/natural hydroxyapatite with chondroitin sulfate (chitosan-CS/HAp) and amylopectin (chitosan-AP/HAp) have been developed for the first time via freeze-drying method and were characterized physicochemically for bone grafting substitutes. Chemical interactions and dispersion of HAp, CS and AP in the chitosan matrix have been evaluated by various analytical techniques. The porosity and water uptake/retention ability of these composite scaffolds decreased whereas thermal stability increased when compared to the chitosan scaffold. The pore size of the chitosan/HAp, chitosan-CS/HAp and chitosan-AP/HAp scaffolds varied from 60 to 180 µm, 60 to 400 µm and 80 to 500 µm, respectively. Cell proliferation, alkaline phosphatase activity and type-1 collagen production was evaluated in vitro using MG-63 cell line, which was observed to be higher in the composite scaffolds. Excellent interconnected porosity, controlled biodegradation and enhanced cell proliferation of the novel chitosan-CS/HAp and chitosan-AP/HAp scaffolds suggests that these scaffolds are promising biomaterials for bone tissue engineering. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Issue Number | 5 |
| Volume Number | 51 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Amylopectin Metabolism Bone And Bones Cytology Chitosan Chondroitin Sulfates Durapatite Tissue Engineering Methods Tissue Scaffolds Alkaline Phosphatase Biosynthesis Animals Biocompatible Materials Chemistry Pharmacology Drug Effects Cell Proliferation Collagen Type I Freeze Drying Perciformes Porosity Water Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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