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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Balasubramanian, Anuradha Durairajpandian, Vishnuprabu Elumalai, Sagadevan Mathivanan, Narayanasamy Munirajan, Arasambattu Kannan Ponnuraj, Karthe |
| Description | Country affiliation: India Author Affiliation: Balasubramanian A ( Centre of Advanced Study in Crystallography and Biophysics University of Madras, Guindy Campus, Chennai 600025, India.) |
| Abstract | Urease is an enzyme that catalyzes the hydrolysis of urea, forming ammonia and carbon dioxide, and is found in plants, microorganisms and invertebrates. Although plant and bacterial ureases are closely related at amino acid and at the structural level, the insecticidal activity is seen only in the plant ureases. In contrast, both plant and bacterial ureases exhibit antifungal activity. These two biological properties are independent of its ureolytic activity. However, till date the mechanism(s) behind the insecticidal and fungicidal activity of ureases are not clearly understood. Here we report the crystal structure of pigeon pea urease (PPU, Cajanus cajan) which is the second structure from the plant source. We have deduced the amino acid sequence of PPU and also report here studies on its stability, insecticidal and antifungal activity. PPU exhibits cellulase activity. Based on the structural analysis of PPU and docking studies with cellopentoase we propose a possible mechanism of antifungal activity of urease. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 58 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Antifungal Agents Chemistry Cajanus Enzymology Insecticides Plant Proteins Seeds Urease Amino Acid Sequence Animals Pharmacology Catalytic Domain Conserved Sequence Crystallography, X-ray Enzyme Stability Fungi Drug Effects Germination Microbial Sensitivity Tests Molecular Docking Simulation Molecular Sequence Data Plant Diseases Microbiology Protein Structure, Secondary Sequence Homology Weevils Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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