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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Khan, Faez Iqbal Wei, Dong-Qing Gu, Ke-Ren Hassan, Md Imtaiyaz Tabrez, Shams |
| Description | Country affiliation: China Author Affiliation: Khan FI ( School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.); Wei DQ ( School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.); Gu KR ( School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.); Hassan MI ( Centre for Interdisciplinary Research In Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 10025, India.); Tabrez S ( King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: shamstabrez1@gmail.com.) |
| Abstract | Determination of the three dimensional (3D) structure of a protein can provide important details about its biological functions and mechanism of action. However, despite their significance, the precise three-dimensional structures of most of the proteins are not fully determined till date. The main focus of the current review article is to gain a better understanding of the structural features of the proteins using computational techniques, and their relationship with function. Protein modeling and design is the method aimed to fold a primary amino acids sequence into protein structure with the ultimate goal of designing novel function and behavior. Moreover, proteins can also be designed from scratch or by similarity with the known protein structure. In the current article we have tried to cover various computer aided protein modeling and designing via homology and ab initio modeling, folding study using Molecular Dynamics (MD) methods and in silico mutation analysis. |
| File Format | HTM / HTML |
| ISSN | 01418130 |
| Volume Number | 85 |
| e-ISSN | 18790003 |
| Journal | International Journal of Biological Macromolecules |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Computational Biology Methods Computer Simulation Models, Molecular Protein Engineering Proteins Chemistry Binding Sites Catalytic Domain Hydrogen-ion Concentration Molecular Docking Simulation Molecular Dynamics Simulation Mutation Protein Conformation Genetics Quantitative Structure-activity Relationship Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Structural Biology Molecular Biology Biochemistry |
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