NDLI: Cellular and developmental control of $O_{2}$ homeostasis by hypoxia-inducible factor 1α

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Cellular and developmental control of $O_{2}$ homeostasis by hypoxia-inducible factor 1α

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Year: 1998 Volume: 12 Issue: 1

Year: 1997 Volume: 11

Cellular and developmental control of $O_{2}$ homeostasis by hypoxia-inducible factor 1α

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Iyer, N. V. Kotch, L. E. Agani, F. Leung, S. W. Laughner, E. Wenger, R. H. Gassmann, M. Gearhart, J. D. Lawler, A. M. Yu, A. Y. Semenza, G. L.
Description	Author Affiliation: Iyer NV ( Center for Medical Genetics, Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914 USA.)
Abstract	Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality. Hypoxia-inducible factor 1 (HIF-1) is the only known mammalian transcription factor expressed uniquely in response to physiologically relevant levels of hypoxia. We now report that in Hif1a-/- embryonic stem cells that did not express the O2-regulated HIF-1alpha subunit, levels of mRNAs encoding glucose transporters and glycolytic enzymes were reduced, and cellular proliferation was impaired. Vascular endothelial growth factor mRNA expression was also markedly decreased in hypoxic Hif1a-/- embryonic stem cells and cystic embryoid bodies. Complete deficiency of HIF-1alpha resulted in developmental arrest and lethality by E11 of Hif1a-/- embryos that manifested neural tube defects, cardiovascular malformations, and marked cell death within the cephalic mesenchyme. In Hif1a+/+ embryos, HIF-1alpha expression increased between E8.5 and E9.5, coincident with the onset of developmental defects and cell death in Hif1a-/- embryos. These results demonstrate that HIF-1alpha is a master regulator of cellular and developmental O2 homeostasis.
File Format	HTM / HTML
ISSN	08909369
e-ISSN	15495477
Journal	Genes & Development
Issue Number	2
Volume Number	12
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	1998-01-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Dna-binding Proteins Physiology Nuclear Proteins Oxygen Metabolism Animals Antigens, Cd31 Blood Vessels Embryology Cell Division Genetics Cell Respiration Cells, Cultured Embryo, Mammalian Pathology Endothelial Growth Factors Homeostasis Hypoxia-inducible Factor 1 Hypoxia-inducible Factor 1, Alpha Subunit Immunoblotting Immunohistochemistry Lymphokines Mice Mice, Inbred C57bl Mice, Knockout Rna, Messenger Stem Cells Time Factors Transcription Factors Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, P.h.s.
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

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Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival.

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Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses

Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model.

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

Cellular and developmental control of $O_{2}$ homeostasis by hypoxia-inducible factor 1α

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Cellular and developmental control of $O_{2}$ homeostasis by hypoxia-inducible factor 1α