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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Miyazaki, T. Takaoka, A. Nogueira, L. Dikic, I. Fujii, H. Tsujino, S. Mitani, Y. Maeda, M. Schlessinger, J. Taniguchi, T. |
| Description | Country affiliation: Japan Author Affiliation: Miyazaki T ( Department of Immunology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113, Japan.) |
| Abstract | Many cytokines transmit signals to the cell interior through activation of receptor-associated, Janus family protein tyrosine kinases (Jak PTKs). The interleukin-2 receptor (IL-2R) is associated with the Jak1 and Jak3 PTKs, and ligand-induced activation of these PTKs is essential for lymphocyte proliferation. Here, the nonreceptor PTK, Pyk2, was found to be activated following IL-2 stimulation in a Jak-dependent manner. Furthermore, physical association was detected between endogenous Pyk2 and Jak3, and a dominant interfering mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation. Collectively, these results suggest that Pyk2 is a newly identified component of the Jak-mediated IL-2 signaling pathway. |
| File Format | HTM / HTML |
| ISSN | 08909369 |
| e-ISSN | 15495477 |
| Journal | Genes & Development |
| Issue Number | 6 |
| Volume Number | 12 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 1998-03-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Milk Proteins Protein-tyrosine Kinases Physiology Receptors, Interleukin-2 Metabolism Binding Sites Drug Effects Cell Division Cells, Cultured Dna-binding Proteins Enzyme Activation Focal Adhesion Kinase 2 Interleukin-2 Pharmacology Janus Kinase 3 Stat5 Transcription Factor Signal Transduction Trans-activators Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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