NDLI: Receptor-mediated endoproteolytic activation of two transcription factors in yeast.

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Receptor-mediated endoproteolytic activation of two transcription factors in yeast.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Andréasson, Claes Ljungdahl, Per O.
Description	Country affiliation: Sweden Author Affiliation: Andréasson C ( Ludwig Institute for Cancer Research, S-171 77 Stockholm, Sweden.)
Abstract	Yeast possess a plasma membrane sensor of external amino acids that functions as a ligand-activated receptor. This multimeric sensor, dubbed the SPS sensor, initiates signals that regulate the expression of genes required for proper amino acid uptake. Stp1p and Stp2p are transcription factors that bind to specific sequences within the promoters of SPS-sensor-regulated genes. These factors exhibit redundant and overlapping abilities to activate transcription. We have found that Stp1p and Stp2p are synthesized as latent cytoplasmic precursors. In response to extracellular amino acids, the SPS sensor induces the rapid endoproteolytic processing of Stp1p and Stp2p. The processing of Stp1p/Stp2p occurs independently of proteasome function and without the apparent involvement of additional components. The shorter forms of these transcription factors, lacking N-terminal inhibitory domains, are targeted to the nucleus, where they transactivate SPS-sensor target genes. These results define a completely unique and streamline metabolic control pathway that directly routes environmental signals initiated at the plasma membrane to transcriptional activation in the nucleus of yeast.
File Format	HTM / HTML
ISSN	08909369
e-ISSN	15495477
Journal	Genes & Development
Issue Number	24
Volume Number	16
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2002-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Carrier Proteins Dna-binding Proteins Metabolism Nuclear Proteins Rna-binding Proteins Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Transcription Factors Ubiquitin-protein Ligases Amino Acids Pharmacology Cell Membrane Cell Nucleus Cycloheximide Genetics F-box Proteins Fungal Proteins Microscopy, Fluorescence Models, Molecular Mutagenesis, Site-directed Peptide Hydrolases Protein Synthesis Inhibitors Drug Effects Signal Transduction Transcription, Genetic Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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