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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lawson, Nathan D. Mugford, Joshua W. Diamond, Brigid A. Weinstein, Brant M. |
| Description | Country affiliation: United States Author Affiliation: Lawson ND ( Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Nathan.Lawson@umassmed.edu) |
| Abstract | In this study, we utilize transgenic zebrafish with fluorescently labeled blood vessels to identify and characterize a mutant (y10) that displays specific defects in the formation of arteries, but not veins. We find that y10 encodes phospholipase C gamma-1 (plcg1), a known effector of receptor tyrosine kinase signaling. We further show that plcg1y10 mutant embryos fail to respond to exogenous Vegf. Our results indicate that Plcg1 functions specifically downstream of the Vegf receptor during embryonic development to govern formation of the arterial system. |
| File Format | HTM / HTML |
| ISSN | 08909369 |
| e-ISSN | 15495477 |
| Journal | Genes & Development |
| Issue Number | 11 |
| Volume Number | 17 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2003-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Arteries Embryology Endothelial Growth Factors Genetics Gene Expression Regulation, Developmental Intercellular Signaling Peptides And Proteins Lymphokines Type C Phospholipases Zebrafish Animals Animals, Genetically Modified Cytology Crosses, Genetic Dna Primers Embryo, Nonmammalian Physiology Heterozygote Detection Molecular Sequence Data Muscle, Smooth, Vascular Phospholipase C Gamma Polymerase Chain Reaction Rna, Messenger Recombinant Proteins Metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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