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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bartolomei, Marisa S. |
| Description | Country affiliation: United States Author Affiliation: Bartolomei MS ( Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. bartolom@mail.med.upenn.edu) |
| Abstract | Genomic imprinting refers to an epigenetic mark that distinguishes parental alleles and results in a monoallelic, parental-specific expression pattern in mammals. Few phenomena in nature depend more on epigenetic mechanisms while at the same time evading them. The alleles of imprinted genes are marked epigenetically at discrete elements termed imprinting control regions (ICRs) with their parental origin in gametes through the use of DNA methylation, at the very least. Imprinted gene expression is subsequently maintained using noncoding RNAs, histone modifications, insulators, and higher-order chromatin structure. Avoidance is manifest when imprinted genes evade the genome-wide reprogramming that occurs after fertilization and remain marked with their parental origin. This review summarizes what is known about the establishment and maintenance of imprinting marks and discusses the mechanisms of imprinting in clusters. Additionally, the evolution of imprinted gene clusters is described. While considerable information regarding epigenetic control of imprinting has been obtained recently, much remains to be learned. |
| File Format | HTM / HTML |
| ISSN | 08909369 |
| e-ISSN | 15495477 |
| DOI | 10.1101/gad.1841409 |
| Journal | Genes & Development |
| Issue Number | 18 |
| Volume Number | 23 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2009-09-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Epigenesis, Genetic Genomic Imprinting Alleles Animals Genetics Evolution, Molecular Gene Expression Regulation Multigene Family Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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