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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tulsawani, Rajkumar |
| Description | Country affiliation: India Author Affiliation: Tulsawani R ( Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110 054, India. rktulsawani@yahoo.com) |
| Abstract | Hippophae rhamnoides, is a high altitude plant, possesses immunomodulatory, anti-oxidant, anti-bacterial and adaptogenic activity and is widely used in treatment of various diseases. The present study was designed to ascertain the safety of aqueous extract of H. rhamnoides fruit when administered by gavage to rats for 90 days. Four groups of animals, each consisting of 15 males and 15 females, were administered 0, 100, 250, or 500 mg/kg extract, in a single dose/day. There were no treatment related change in mean body weight, organ/body weight ratio, histological, hematological and biochemical parameters studied in rats of either sex administered with extract at any dose evaluated. However, a significant increase in plasma glucose levels was observed in animals supplemented with 250 or 500 mg/kg extract, which returned to normal after a 2-week withdrawal of treatment. These results indicate no adverse effects of extract at a dose of 100mg/kg body weight/day in rats administered for 90-days. Based on the findings of this study, the NOAEL was 100mg/kg body weight/day of aqueous fruit extract of seabuckthorn in rats. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 8-9 |
| Volume Number | 48 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Hippophae Toxicity Animals Blood Cell Count Blood Chemical Analysis Blood Glucose Metabolism Body Weight Drug Effects Dose-response Relationship, Drug Female Chemistry Intubation, Gastrointestinal Male No-observed-adverse-effect Level Organ Size Phenols Analysis Plant Extracts Rats Rats, Inbred F344 Rats, Sprague-dawley Sex Characteristics Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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