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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kothari, Shil C. Shivarudraiah, Prasad Venkataramaiah, Suresh Babu Koppolu, Kesavan Poonimangadu Gavara, Swapna Jairam, Ravikumar Krishna, Suhasini Chandrappa, Ravindra K. Soni, Madhu G. |
| Description | Country affiliation: United States Author Affiliation: Kothari SC ( Gateway Health Alliance Inc., 4769 Mangels Blvd, Fairfield, CA 94534, USA.) |
| Abstract | Cissus quadrangularis has been used for centuries for therapeutic and culinary purposes. Extract from this plant (CQR-300) has been claimed for its health benefits. The objective of present investigation was to delineate adverse effects, if any, of CQR-300 in subchronic toxicity, and gentotoxicity studies. In the subchronic study, Sprague Dawley rats (20/sex/group) were administered (gavage) C. quadrangularis extract (CQR-300) at dose levels of 0, 100, 1000, and 2500 mg/kg body weight (bw)/day for 90 days. No treatment related clinical signs of toxicity, mortality or changes in body weights, body weight gain or food consumption were noted. Functional observation tests and ophthalmological examination did not reveal any changes. No toxicologically significant treatment related changes in hematological, clinical chemistry, urine analysis parameters, and organ weights were noted. No treatment related macroscopic and microscopic abnormalities were noted at the end of treatment period. The results of mutagenicity studies as evaluated by Ames assay, in vitro chromosomal aberration and in vivo micronucleus assay did not reveal any genotoxicity of CQR-300. Based on the subchronic study, the no-observed-adverse-effect level (NOAEL) for C. quadrangularis extract (CQR-300) determined as 2500 mg/kg bw/day, the highest dose tested. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 12 |
| Volume Number | 49 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Cissus Chemistry Plant Extracts Pharmacology Toxicity Tests, Subchronic Methods Administration, Oral Animals Body Weight Drug Effects Dose-response Relationship, Drug Drug Evaluation, Preclinical Female Male Micronucleus Tests No-observed-adverse-effect Level Organ Size Rats Rats, Sprague-dawley Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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